Inhaled vaccine induces strong immune response in animal models
Scientists report their phage-based inhaled vaccine delivery system elicited a robust antibody response in both mice and non-human primates.
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Brain organoids used to identify promising treatments for Rett syndrome
Two drugs, Nefiracetam and PHA 543613, were able to return neuronal signalling to near normal in organoids derived from patients with the autism spectrum disorder, Rett syndrome.
Studies in mice reveal link between obesity and tumour growth
New research has provided a metabolic atlas for insights into obesity and tumours' ability to hide from the immune system.
Novel target could treat both SARS-CoV-2 and other coronaviruses
Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.
Non-hallucinogenic version of ibogaine could treat addiction and depression
A non-hallucinogenic version of the psychedelic drug ibogaine could treat psychiatric disorders, pre-clinical trials have shown.
Biomarker for blood vessel damage found in children with SARS-CoV-2
Elevated levels of a biomarker related to blood vessel damage have been found in all children with SARS-CoV-2 infection.
Mitochondrial replacement therapy (MRT) shown to be safe in monkeys
A long-term study of macaques given mitochondrial replacement therapy (MRT) found that both treated individuals and their offspring were healthy and developed normally.
Role of gene in metastasis of brain cancer revealed
Researchers have shown how increased YTHDF3 expression correlates with brain cancer metastases, making it a target for the condition.
Inhibiting cadherin 11 significantly increases survival of mice with pancreatic cancer
Mice treated with a small molecule inhibitor of cadherin 11 (CDH11) had reduced pancreatic cancer growth and increased survival time.
Red propolis could be a better treatment for schistosomiasis
Investigators found that red propolis can kill schistosomes at all stages of development and therefore suggest it could be highly effective for treating schistosomiasis.
Triggering an IgA response could increase COVID-19 vaccine efficacy
Two new studies suggest that SARS-CoV-2-specific IgA antibodies are more neutralising and therefore COVID-19 vaccines should encourage an IgA response.
Synthetic llama antibodies used to rescue mutated proteins
Engineered deubiquitinases combines a synthetic nanobody that recognises a protein that can rescue proteins tagged for destruction.
Proteomics study to investigate plasma proteins in 53,000 participants
Next-generation sequencing will be employed to study 1,500 plasma proteins in participants, according to UK Biobank.
Novel target for pulmonary fibrosis identified using tissue from COVID-19 patients
Study suggests reducing the expression of the methyl-CpG-binding domain 2 (MBD2) protein on macrophages could be a viable therapeutic strategy for lung fibrosis.
New embryonic stem cell type could advance regenerative medicine
Scientists suggest that research using XPSCs, an intermediate form of embryonic stem cell, could help accelerate the development of stem cell-derived tissues and organs for transplantation.