Antibodies from previous COVID-19 infection protect patients for six months
A study in healthcare workers has shown that antibodies from COVID-19 infection protect individuals from reinfection for at least six months.
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Novel inhibitor kills brain cancer cells missing ENO1 in mice, study shows
In pre-clinical studies, researchers have shown that a new therapy called POMHEX can destroy brain cancer cells that were missing one of two genes encoding the enolase enzyme.
MALP cells as a potential target for osteoporosis drug development
Researchers have found that bone marrow adipogenic lineage precursor (MALP) cells may initiate the production of osteoclasts and drive bone remodelling in osteoporosis.
Drug target and candidate for paediatric heart failure identified
A group of researchers has found a drug candidate named TRV027 that can increase the cardiac contractility of neonatal mice.
Antibody effector functions are key to combatting COVID-19, finds study
Rodent studies show that using antibodies with different targets and modes of action in combination is more effective at preventing and treating COVID-19.
Researchers reveal how coronaviruses use protein vibrations to enter cells
Using atomistic simulations, a team has demonstrated how coronavirus Spike proteins move and vibrate to let the virus through cell walls.
Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers
Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.
Compound that prevents replication of SARS-CoV-2 identified by researchers
Researchers say that the Ebselen compound can inhibit the replication of SARS-CoV-2 in the laboratory, so could combat COVID-19.
Mini lung organoids replicate COVID-19 pathology in a dish
Scientists developed a new culture technique for alveolospheres which they used to study how alveolar cells respond to SARS-CoV-2 infection.
Researchers identify potential compound to inhibit inflammation
Researchers have found a compound that can prevent up-regulation of CD14, a key inflammatory protein, in cells.
£4 million in funding announced to collect data on COVID-19 antibodies
UKRI will provide £4 million in funding to establish a data infrastructure for scientists in the UK to study antibodies from COVID-19 patient samples.
CRISPR-based treatment successfully targets glioblastoma and ovarian cancers in vivo
Researchers say this is the first time that CRISPR-Cas9 gene editing has been used to treat cancer effectively in a living animal and that the technique could be revolutionary.
Researchers identify three drugs that could be repurposed for COVID-19
The candidates were screened based on their similarity to hydroxychloroquine and tested for efficacy against SARS-CoV-2 in vitro.
Potential strategy to treat COVID-19-related cytokine storms identified
Researchers have found that neutralising antibodies for the TNF-alpha and IFN-gamma cytokines can prevent death from SARS-CoV-2 in mice.
Novel synthetic method enables production of cytotoxic compounds
Researchers say their new process enables the synthesis of phenazinones, some of which have high selective toxicity for cancer cells and could be promising anticancer drugs in future.