PI3K signalling pathway revealed as potential drug target for obesity
Researchers have found that the PI3K signalling pathway could be targeted to prevent liptoxicity and combat obesity.
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Scalable method to image protein levels and changes developed
Using a new CRISPR-Cas9 tagging strategy, researchers have developed a method that enables the imaging of hundreds of proteins in parallel.
Hepatitis C drugs could combat SARS-CoV-2, researchers find
Researchers have identified hepatitis C drugs that can inhibit the SARS-CoV-2 main protease, which enables the coronavirus to reproduce.
Novel technique reveals Parkinson’s changes how neurons sense oxygen
The new approach enables researchers to isolate brain cells associated with Parkinson's disease and study their gene expression patterns.
CBD molecule has potential to treat rare skin diseases, study shows
Researchers have found that CBD induces an enzyme with antioxidant and anti-inflammatory properties in the top layer of the skin.
COVID-19 vaccine tablet significantly reduces viral load in hamsters
Hamster challenge study results suggests the oral COVID-19 vaccine induces a robust immune response, protecting the animals from infection.
LMTK3 inhibitors could be an effective breast cancer therapy, say scientists
Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.
Primate model used to explore features of SARS-CoV-2 infection
The non-human primate model exhibited a COVID-19-like disease and showed how symptoms and viral activity change over the course of SARS-CoV-2 infection.
‘Neuroregenerative’ study uses glial cells for stroke repair in primates
In rhesus macaques, a team were able to induce neural regeneration from brain internal glial cells, repairing damage from stroke.
Researchers suggest SKI complex of SARS-CoV-2 as novel drug target
Researchers have discovered new drug compounds that target the SKI complex of SARS-CoV-2, preventing replication.
New 3D cell culture method could enable personalised cancer therapies
A team has extracted single tumour cells from existing cell lines to create 3D cell cultures that could allow for personalised cancer therapies.
Scientists unveil virtual reality tool for COVID-19 drug development
The tool uses interactive molecular dynamics simulations in virtual reality (iMD-VR) to allow researchers to step inside SARS-CoV-2 enzymes and visualise molecules binding to them.
Researchers dicover novel targets for rheumatoid arthritis therapies
Researchers have identified that autoreactive B cells and a protein that enables them to invade joints could be promising drug targets for the most common inflammatory arthritis.
Researchers reveal structure of SARS-CoV-2 Envelope protein
The molecular structure of the SARS-CoV-2 Envelope protein has been identified by researchers using nuclear magnetic resonance.
Furin cleavage motif makes SARS-CoV-2 more aggressive than other CoVs, find scientists
A specific furin cleavage motif on the SARS-CoV-2 Spike protein, not present on other coronaviruses (CoVs), could be targeted by novel COVID-19 therapies.