Developing drugs for disordered proteins
Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.
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Children produce a different antibody response to SARS-CoV-2 infection, finds study
A new analysis reveals that the course of SARS-CoV-2 infection and the immune response it provokes is completely different in adults and children.
Team identifies new potential approach to treat multiple sclerosis
Researchers have prevented immune cells from attacking myelin in mice, which stopped the progression of multiple sclerosis (MS).
D614G mutation may make SARS-CoV-2 more contagious
According to a new study, the SARS-CoV-2 virus is accumulating genetic mutations, including one called D614G which may have made it more contagious.
Protease inhibitor aprotinin shows promise against SARS-CoV-2 in cells
Researchers have found that aprotinin, an approved drug for influenza in Russia, combats SARS-CoV-2 in cells.
Novel therapeutic approach shows promise in mice with COPD
By blocking the lymphotoxin beta receptor signalling pathway, researchers were able to prevent COPD progression and induce a full restoration of lung tissue.
Midbrain organoids developed for automated chemical screening
Researchers have used small molecule neural precursor cells to develop midbrain organoids that enable drug effects to be assessed in a complex cell environment.
Persistence of infected cells in lungs could explain long-term COVID-19 symptoms, say scientists
Researchers have found the genome of COVID-19 and infected cell syncytia in the respiratory cells of deceased patients, potentially explaining long-term coronavirus effects.
Age may be a primary determinant of melanoma treatment resistance
Scientists have shown that age may cause genetically identical melanoma skin cancer cells to respond differently to treatment, making age a primary factor in treatment response.
Exosome-educated macrophages show potential to treat ligament injuries
In a new rodent study, researchers show how delivering exosome-educated macrophages (EEMs) can accelerate the repair of ligament damage, while simultaneously reducing inflammation and scarring.
Researchers use somatostatin to treat Alzheimer’s in mice
A team fused the peptide somatostatin to a brain transport protein and found it treated memory loss associated with Alzheimer's in mice.
Using machine learning to guide and enhance bioengineering
The Automated Recommendation Tool (ART) uses machine learning to accelerate the development of cells for specified goals, eg, bioprocessing and bioproduction.
Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots
According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.
Researchers reveal how allergens may trigger itching
Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.
SARS-CoV-2 can disrupt the blood-brain barrier, find scientists
Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.