Epigenetic dysregulation mechanism in Crohn’s disease discovered
Intestinal epithelial organoids highlight a pathway implicated in CD, named major histocompatibility complex (MHC)-I.
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Intestinal epithelial organoids highlight a pathway implicated in CD, named major histocompatibility complex (MHC)-I.
A new study reveals that pain management could be greatly improved by considering patient sex as fundamental.
Researchers found, using human respiratory epithelium organoids, that P. aeruginosa breaches respiratory epithelia by goblet cell invasion.
The development of a new membrane which better mimics human extracellular membranes will enable more accurate disease research.
Researchers have identified a new biological pathway driving IBD and similar conditions that could be targeted with MEK inhibitors.
A human pancreatic cancer fibrotic barrier model illuminates how targeting the TGFβ/ROCK2/YAP signalling axis could enhance drug delivery.
A new immunotherapy approach combining co-engineered T cells and antibodies enhances phagocytosis of tumour cells.
Through multi-omics analysis, researchers find that oestrogen signalling could be a target for never-smoker lung cancer cases.
Researchers have developed a new, compact EbCas12a variant that can be packaged into an all-in-one AAV system with its crRNA.
Researchers discovered that HER2-positive breast cancer drugs must target both HER2 and EGFR receptors to eradicate disease.
Topological defects in mesenchymal stromal cell self-assembly could suggest their potential for cartilage regeneration.
Researchers found that relaxing glial spacing by targeting Plexin-B1 has great therapeutic potential for Alzheimer’s disease.
A novel drug, JHU083, turns into its active, glutamine-blocking form inside tumours, shrinking prostate and bladder cancers in mice.
This is the first study to demonstrate that a specific set of HERVs expressed in the human brain contribute to disorders like schizophrenia.
The world’s first generation of human BBB organoids from hPSCs accurately replicated features of cerebral cavernous malformation.