Circular RNA revealed as drug target for lung squamous cell cancer
After finding that the circular RNA called CDR1as plays a role in driving metastasis, researchers have identified it as a potential target for lung squamous cancer.
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Natural pigment could transform long-term toxicology studies
A natural pigment from Monascus purpureus can be used to stain cells and distinguish between live and dead ones in toxicology studies.
Interactive 3D model of SARS-CoV-2 surface released
A new interactive map of the surface of SARS-CoV-2, featuring the Spike, Envelope and Membrane proteins, has been released for researchers to use.
Pathway to combat chronic myelogenous leukaemia identified in study
Researchers have discovered that disrupting the Gdpd3 gene significantly reduced chronic myelogenous leukaemia relapse in mice.
Team reveals why children’s immune response to COVID-19 is better than adults’
Researchers have identified two molecules that explain why children experience COVID-19 differently to adults.
Researchers identify drug target for treatment of malabsorption in babies
Scientists have found a hormone peptide called YY that presents a promising drug target for malabsorption in babies.
Disrupted RNA transportation results in neurodegeneration
Researchers report that reduced TDP-43 expression disrupts axonal transport of messenger RNAs to cause neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).
Experimental antiviral AR-12 could be a promising COVID-19 treatment
Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.
Assay that mimics SARS-CoV-2 infection could test potential COVID-19 drugs
Scientists have developed a new assay that uses nanoparticles to mimic how SARS-CoV-2 infects a cell, which could be used to screen for drugs that treat COVID-19.
Treg cells could be used in immunotherapy to treat multiple sclerosis, study shows
Researchers have discovered how Tregs can reduce spinal cord injury caused by diseases like multiple sclerosis (MS).
Researchers discover druggable pocket on SARS-CoV-2 Spike protein
A pocket in the SARS-CoV-2 Spike protein has been discovered by researchers, who say it could be a drug target for COVID-19.
Lethal poxviruses could be rendered harmless with single gene removal
Researchers report that removing the vSLFN gene from the ectromelia virus (ECTV) caused a potent immune response which protected animal models.
4-PBA could prevent cytokine storm in severe COVID-19
Scientists explore whether the anti-stress drug, 4-Phenylbutiric acid (4-PBA), could prevent cytokine storms causing respiratory failure in COVID-19 patients.
Psychedelic drug discovery enabling discovery of new psychiatric drugs
Having resolved the structure of psychedelic drugs bound to the 5-HT2A serotonin receptor researchers are now developing new therapeutic drugs.
Novel pseudo-virion probes to study SARS-CoV-2 viral entry
The non-infectious quantum dot probes are designed to enable researchers to safely study interactions between the SARS-CoV-2 Spike (S) protein and human cells.