Investigating CWD transmission with human cerebral organoid models
Following direct exposure of human CNS tissues to CWD prions, a significant resistance to the propagation of infection was found.
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Following direct exposure of human CNS tissues to CWD prions, a significant resistance to the propagation of infection was found.
Researchers have elucidated how Slc4a4 governs astrocyte-endothelial cell interaction in blood-brain barrier maintenance and repair.
Culture conditions during embryoid body formation can be enhanced to gain glia-associated proteins and neural network activity.
Researchers identified miR-519a-3p as a biomarker that could enable early diagnosis and treatment of neurodegenerative diseases.
In assays and patient-derived organoids, the small molecule inhibitor CBR-5884 successfully treated epithelial ovarian cancer.
The discovery that CNTN4 and APP have a co-dependent relationship has wider implications for neurodevelopmental disorder understanding.
Researchers identified variants in three loci that were associated with risk of triple-negative breast cancer.
The experimental therapy eliminated 90 percent of HSV-1 after facial infection and 97 percent of HSV-1 after genital infection.
Researchers uncover a genetic pathway of parietal cell development, which will enable a better understanding of stomach conditions.
Heightened insulin resistance in obese men may elucidate the higher prevalence of type 2 diabetes among these individuals.
The new study provides proof of principle that functional liver cells can be grown in a different species, offering a potential solution to transplant shortage.
The discovery that omental fat has a mechanism to limit adipocyte formation may lead to new treatments for obesity and metabolic disease.
Through in vitro and in vivo models, researchers find a mechanism by which bacteria-generated fatty acids regulate immune responses.
The screening model combines maternal history, ultrasound data and several tests for blood markers to enable personalised treatment.
A specialised drug-loaded nanoparticle, which can cross the blood-brain barrier, shrunk both breast tumours and breast cancer cells.