New insights into human and mouse genomes published in NIH study
The third phase of the ENCODE project has been released, with new information on genes and their potential regulators in their respective genomes.
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PLpro inhibitors support immune response to COVID-19 in cell cultures
Researchers have found that using GRL-0617, an PLpro inhibitor, in cell cultures blocked SARS-CoV-2 production and supported the cell immune response.
Over 200 genes implicated in glioblastoma tumour growth
A study has identified more than 200 genes that drive the progression of glioblastoma and which the researchers say present drug targets.
Team suggest bradykinin system could be targeted by COVID-19 drugs
Researchers say computational analyses suggest the bradykinin system may explain some of the symptoms of COVID-19, providing a drug target.
SRI-37330 revealed as drug candidate for treatment of diabetes
A study has shown that SRI-37330 is successful at improving the characteristics of diabetes in human pancreatic islets and animal models.
LY6E identified as potential immunoprotein against SARS-CoV-2
A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.
High-throughput screening reveals 21 drugs with activity against COVID-19
After screening 12,000 existing drugs, scientists have identified 21 which prevent the replication of SARS-CoV-2 in concentrations safe for patients.
Study reveals microRNA as promising hair regrowth drug target
Researchers have revealed that the microRNA miR-218-5p promoted hair growth in mice, so is a promising drug target for hair loss.
Technique to visualise hundreds of genomes simultaneously developed
A new technology named OligoFISSEQ has been created which can image and three-dimensionally map the genomes in hundreds of cells at the same time.
Researchers identify sEH enzyme as novel Alzheimer’s drug target
A team has shown that inhibiting the soluble epoxide hydrolase (sEH) enzyme in murine models can prevent the cognitive deterioration associated with Alzheimer's.
Seaweed extract outperforms remdesivir as COVID-19 therapy in vitro
According to new research, sulfated polysaccharides extracted from seaweed were more effective at inhibiting SARS-CoV-2 infection in mammalian cells than remdesivir.
Breakthrough made in herpes antiviral molecule development
Researchers have created a new method of potentially treating herpes virus, by targeting the physical properties of the viral genome.
Team redesigns COVID-19 Spike protein for more stable vaccines
Researchers have modified the COVID-19 Spike protein for use in vaccines, which produces up to 10 times more protein than that of an earlier synthetic versions.
Imaging and machine learning system created to discover tuberculosis drugs
Researchers have developed MorphEUS, a technology to identify new drugs that combat M. tuberculosis by revealing how compounds destroy the bacteria.
Novel CRISPR C-to-G DNA base editor developed by researchers
A new CRISPR technology has been created to understand mutations based on cytosine to guanine base changes and minimise unintended "off-target" mutations.