Screening reveals rocaglate compounds kill C. auris
Researchers have screened over 2,000 compounds to discover that rocaglates effectively combat C. auris, offering a potential new treatment.
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COVID-19 viral envelope simulation under development
Researchers are working to build a complete, all-atom model of the exterior of the coronavirus to aid in drug design.
Connections between nerves and stem cells may be essential for function
Researchers have demonstrated that stem cells attract neurons with different strengths and that connections between the two may be vital for cancer stem cell function.
CRISPR discovery could be used to combat multi-drug resistant bacteria
A study has shown that plasmids use type IV CRISPR-Cas against competing plasmids, leading the researchers to suggest the method as a novel way to tackle multi-drug resistant bacteria.
Cannabidiol identified as potential ‘helper’ compound for antibiotics
Researchers have found that using antibiotics in combination with cannabidiol (CBD) enhanced their effect against Staphylococcus aureus bacteria.
New mass spec technique used to determine structure of sugars
A new method has been invented that boosts the mapping of heparan sulfates and which the researchers say could be widely used for drug discovery.
Map of COVID-19 and human protein interactions reveals drug targets
Researchers have identified which SARS-CoV-2 proteins physically associate with proteins in human cells, revealing potential drug targets to treat the COVID-19 coronavirus.
Human tuberculosis blood signal replicated in mice
More research into tuberculosis is now possible with the development of an optimisied mouse model that exhibits the same blood immune response to Mycobacterium tuberculosis infection as humans.
Chronic use of heart disease medications may increase the risk of severe COVID-19
A researcher has revealed that angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) may increase the risk of severe lung complications in COVID-19.
UK Consortium to monitor spread and behaviour of coronavirus
The UK government has invested £20 million into the COVID-19 Genomics UK Consortium, which will use whole genome sequencing to inform infection control measures and therapeutic developments.
Early natural killer cells more effective than adult versions, find researchers
Researchers have shown that natural killer (NK) cells work best as an immunotherapy when in an early stage of development, so could be manufactured from pluripotent stem cells.
COVID-19 research hub: promoting scientific collaboration
Drug Target Review has created a COVID-19 research hub with forum space for discussions and a place to share your research - plus all of our articles and news.
New compound could alleviate side effects of antidepressant drugs
Researchers have revealed a new substance that can bind well to serotonin transporters, offering a potential way to lessen the side effects of antidepressant therapies.
Researchers to screen compound library for antiviral drugs to combat COVID-19
Scripps Research has announced it will screen over 14,000 compounds to see if any present significant activity against COVID-19, for use in a therapeutic.
Scientists propose new precise method to measure atoms
A team of Russian scientists has suggested a new method to measure the sizes of atoms as well as their intermolecular interactions, which they say could help drug design.