B-ALL: combination therapy effectively controls high-risk subtypes
The combination therapy worked faster and was lessened the number of leukaemia cells compared to asparaginase or venetoclax alone.
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KCNJ2 inhibition: a therapeutic target for traumatic brain injury
Using cortical organoids, researchers discovered that targeting KCNJ2 could reduce nerve cell death after TBI.
Atlas of the human ovary offers huge potential for new treatments
Single-cell RNA sequencing of ovaries resulted in the identification of four major cell types and four immune cell subtypes.
Investigating new treatments for polycystic kidney disease
Organoid models enabled the researchers to study the effectiveness of eukaryotic ribosomal selective glycoside drugs on PKD cyst formation.
Exploring the effects of IFNβ in neuroHIV infection
IFNβ could be developed into a new therapy, following an improved understanding of how innate immunity affects the brain during chronic HIV infection.
Rare genetic variants found to have a large impact on obesity risk
Researchers have gained a deeper understanding of the neural biology of obesity, which could offer potential drug targets.
Exploring the conditions in which pathological 4R tau misfolds
Researchers have presented new findings that offer potential pathways to arrest critical steps toward the accumulation of mutant tau.
New treatment for metabolic dysfunction-associated steatohepatitis
The compound 11c demonstrates an excellent safety profile and is an exciting advancement in liver disease management.
Combatting T-cell tumours with antibody drug conjugates
One treatment with the anti-TRBC1-SG3249 ADC combination saw cancer elimination within seven days in mouse models.
Reversing malignant cancer cells to a normal state
A new proof-of-principle study demonstrates the DCAF5 protein is a promising target, which could avoid the need for toxic therapies.
Hereditary Alzheimer’s disease can be transferred via transplants
Transplant recipients of hematopoietic stem cells with a hereditary version of AD developed the disease at an accelerated rate.
New trivalent vaccine for clade 1 sarbecoviruses
The vaccine provided complete protection with no detectable virus in the lungs and could be a routine part of people’s medical treatment.
Uncovering the functional role of sRNAs in bacterial adaptation
Researchers find how antibiotic treatments influence the microbiota, providing new strategies for preventing antibiotic-induced damage.
MUTYH variants implicated in a broader range of cancers
The discovery that one missing copy of MUTYH could increase the risk of cancers may lead to therapeutics against solid tumours.
Blastoids enable greater understanding of human gastrulation
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.