Blocking bacterial competence could prevent antibiotic resistance
Scientists suggest competence-blocking, ‘anti-evolution’ drugs could be administered alongside antibiotics to prolong the period before bacterial resistance emerges.
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Mitochondria-boosting compound promotes immunotherapy in mice
Researchers have discovered that a small molecule can help some T cells combat tumours during PD-1 blockade immunotherapy in mice.
Compound effective against bacterial superbugs discovered
Researchers have developed a compound, called AB569, effective at combatting bacteria such as Pseudomonas aeruginosa and have revealed its mechanism of action.
Researchers create new Cas9 variant to reduce off-target CRISPR edits
A study has shown that altering amino acid residues in Cas9 to produce new variants can produce a vector with increased gene editing specificity.
Skin inflammation in Netherton syndrome linked to Staphylococcal bacteria
Research indicates both S. aureus and S. epidermidis exacerbate skin inflammation, so could be targeted to help treat Netherton syndrome.
Multi-organ-on-a-chip developed for drug toxicity screening
The model was tested on a panel of drugs that are both still on the market or have been recalled due to adverse effects and was able to show their toxicity.
Mechanism of action revealed for remdesivir, potential coronavirus drug
Researchers have demonstrated how the drug known as remdesivir works, presenting the viral RNA polymerase of coronaviruses as a target for these conditions.
ZT-1a compound could be an alternative to surgery for brain swelling
Rodent models of stroke and hydrocephalus treated with ZT-1a had reduced brain swelling, according to scientists.
Mass spectrometry approach allows researchers to make precise protein measurements
A new method for weighing proteins at the atom level, called individual ion mass spectrometry, has been developed by American researchers.
Researchers find drug improves cancer immunotherapy in mice
A study has shown that in mice, the GKT137831 drug makes tumours more sensitive to immunotherapy, so could be used to improve cancer treatments.
Stainless imaging developed by adding infrared to standard microscopes
A new method to image cancerous tissues has been created by researchers who have paired infrared measurements with high-resolution optical images.
Novel antibody breaks bacterial biofilms and prevents sepsis in mice
A new monoclonal antibody has been discovered which disassociates bacterial biofilms and stops bacteria from entering into circulation has been tested in mice.
New gene therapy for Huntington’s demonstrates success in mice
Researchers have developed a new regenerative gene therapy using neurogenic differentiation, which has shown efficacy treating Huntington's disease in mice.
Inhaling stem cell secretome could be a more effective pulmonary fibrosis treatment
Rodent models of pulmonary fibrosis have been used to show that lung spheroid cell secretome therapy is as effective as stem cell secretome treatment.
Metal-containing compounds could lead to new antibacterials
International collaboration has shown that compounds with metals in them show antibacterial activity against MRSA, E. coli and A. baumannii.