Researchers generate atlas of thymus to understand T-cell development
A new study has created an atlas of human thymus development, to reveal which genes are needed for the production of specific T cells.
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Compound combination successful against Pseudomonas aeruginosa
Researchers have developed a new combination of compounds called AB569 which has demonstrated success at fighting deadly pathgoens like Pseudomonas aeruginosa.
RCAN1 gene revealed as regulator of Down syndrome symptom
A study has shown that the RCAN1 gene plays a role in regulating synaptic plasticity, which contributes to a sympom of Down syndrome.
ILC2s sensitise pancreatic tumours to PD-1 checkpoint inhibitors in mice
Scientists identify innate lymphoid cells (ILCs) as possible targets for immunotherapies as their activation makes murine pancreatic tumours sensitive to PD-1 checkpoint inhibitors.
Utrophin as a novel therapeutic approach for Duchenne muscular dystrophy
Upregulating utrophin using small molecules could be a new therapeutic approach for Duchenne muscular dystrophy (DMD).
New laser system developed for stainless imaging of vesicles
Using ultrashort laser pulses to interact with vesicles, researchers have created a novel label-free imaging method.
Toll-like receptor could be targeted to treat age-related macular degeneration
Scientists have implicated toll-like receptor 2 (TLR2) in age-related macular degeneration and shown that knocking it out can improve symptoms in animal models.
Novel antibiotic compound revealed through artificial intelligence screening
A new antibiotic compound has been identified by researchers who designed a machine-learning algorithm to screen millions of molecules.
L-serine could be used to treat ALS, after promising results in primate study
Researchers have shown that, when treated with L-serine, a non-human primate model of ALS had fewer pathologies associated with the disease.
New therapy stops seizures in mouse model of rare childhood epilepsy
A rare form of childhood epilepsy could be improved with a therapy called antisense oligonucleotide, following the development of a new model.
Using blue light to control CAR T cells and destroy tumours
Researchers have created a method to activate CAR T cells with blue LED light to successfully combat solid tumours in mice.
New worm model could aid in the study of rare disease
A new earthworm model has been developed for the rare disease, x-ALD, which the scientists say could lead to pharmacological targets for the neuronal alterations of the disease.
Single cancer cells in lab-grown tumours analysed with new technology
New technology is for the first time enabling scientists to analyse the individual behaviour of millions of different cells living inside lab-grown tumours, which could lead to new personalised cancer treatments.
Ptychographic label-free microscopy platform developed for imaging
Researchers have developed a new label-free ptychographic microscopy method by bringing samples closer to the image sensor, reducing processing time.
High-throughput screening reveals new compound to maintain lung health
Researchers have screened 20,000 molecules to discover a potent compound with low toxicity that restores the balance of healthy stem cells in the lungs of mice.