Key modifier identified in genetic deletion related to autism
A key modifier has been identified by researchers in a large fruit fly genetic deletion related to neurodevelopmental disorders such as schizophrenia and autism.
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Lettuce used to create pulmonary arterial hypertension protein treatment
Researchers have developed a way to produce proteins from lettuce which can effectively combat pulmonary arterial hypertension in animals.
WDR74 protein identified as lung cancer and melanoma therapeutic target
Researchers have revealed that the WDR74 protein plays a key role in lung cancer and melanoma, including metastasis, indicating it may be a potential drug target.
Artificial intelligence trained to find disease-related genes
Researchers have developed an artificial neural network using deep learning to identify genes that are related to disease.
New variant of the GLA gene to be linked with Fabry cardiomyopathy
A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.
Hub for tech companies opens at Alderley Park, UK
Alderley Park has announced the opening of Glasshouse, its work space for tech enterprises looking to work collaboratively in drug discovery.
Remdesivir demonstrates success against MERS in rhesus macaques
The experimental remdesivir drug has shown efficacy in combatting the MERS virus in rhesus macaques, according to a new US study.
YAP protein identified as new target for Alzheimer’s disease
Researchers have discovered that neuronal necrosis occurs in Alzheimer's earlier than previously though and revealed the YAP protein as a potential target.
Increasing NAD levels could improve quality of eggs, says research
A study has identified that infertility due to age-related defects in eggs could be improved by raising levels of NAD, presenting a possible novel fertility treatment.
Murine model for coeliac disease may lead to future therapies, say researchers
Using an innovative approach to create a model organism, scientists have translated human research into a murine model which they say more accurately reflects coeliac disease.
Class of antibiotics with unique mechanism to combat bacteria discovered
Researchers have uncovered new antibiotics which prevent bacteria from multiplying, offering a strategy to fight infections.
CRISPR ‘minigene’ used to prevent genetic liver disease in mice
Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.
Using Ebola’s immune evasion mechanism to target glioblastoma
An innovative chimeric vaccine containing an Ebola gene that helps the virus evade the immune system has been used to selectively target and kill glioblastoma in mice.
Researchers develop screening platform to detect new antibiotics
A new technology developed by scientists combines small molecule screening methods with machine learning algorithms to identify novel antibiotics that inhibit ribosomes.
Carbon hydrogen functionalisation could provide new route for synthesising compounds
The carbon hydrogen functionalisation process could be used to make 3D scaffolds for pharmaceutical compounds, say researchers.