Novel technique creates complex synthetic drug molecules 18 February 2020 | By Victoria Rees (Drug Target Review) A new method has been developed by researchers to create synthetic molecules which replicate natural structures and have potential medicinal uses.
Myc gene linked to alternative splicing changes in several cancers 18 February 2020 | By Mandy Parrett (Drug Target Review) A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.
European patent upheld for foundational CRISPR-Cas9 intellectual property 18 February 2020 | By Victoria Rees (Drug Target Review) Arguments filed in opposition to a patent for foundation CRISPR-Cas9 intellectual property have been broadly rejected by the European Patents Office.
Key modifier identified in genetic deletion related to autism 18 February 2020 | By Rachael Harper (Drug Target Review) A key modifier has been identified by researchers in a large fruit fly genetic deletion related to neurodevelopmental disorders such as schizophrenia and autism.
Lettuce used to create pulmonary arterial hypertension protein treatment 17 February 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a way to produce proteins from lettuce which can effectively combat pulmonary arterial hypertension in animals.
WDR74 protein identified as lung cancer and melanoma therapeutic target 17 February 2020 | By Victoria Rees (Drug Target Review) Researchers have revealed that the WDR74 protein plays a key role in lung cancer and melanoma, including metastasis, indicating it may be a potential drug target.
Artificial intelligence trained to find disease-related genes 17 February 2020 | By Victoria Rees (Drug Target Review) Researchers have developed an artificial neural network using deep learning to identify genes that are related to disease.
New variant of the GLA gene to be linked with Fabry cardiomyopathy 17 February 2020 | By Mandy Parrett (Drug Target Review) A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.
Hub for tech companies opens at Alderley Park, UK 14 February 2020 | By Victoria Rees (Drug Target Review) Alderley Park has announced the opening of Glasshouse, its work space for tech enterprises looking to work collaboratively in drug discovery.
Remdesivir demonstrates success against MERS in rhesus macaques 14 February 2020 | By Victoria Rees (Drug Target Review) The experimental remdesivir drug has shown efficacy in combatting the MERS virus in rhesus macaques, according to a new US study.
YAP protein identified as new target for Alzheimer’s disease 14 February 2020 | By Victoria Rees (Drug Target Review) Researchers have discovered that neuronal necrosis occurs in Alzheimer's earlier than previously though and revealed the YAP protein as a potential target.
Increasing NAD levels could improve quality of eggs, says research 14 February 2020 | By Hannah Balfour (Drug Target Review) A study has identified that infertility due to age-related defects in eggs could be improved by raising levels of NAD, presenting a possible novel fertility treatment.
Murine model for coeliac disease may lead to future therapies, say researchers 13 February 2020 | By Hannah Balfour (Drug Target Review) Using an innovative approach to create a model organism, scientists have translated human research into a murine model which they say more accurately reflects coeliac disease.
Class of antibiotics with unique mechanism to combat bacteria discovered 13 February 2020 | By Victoria Rees (Drug Target Review) Researchers have uncovered new antibiotics which prevent bacteria from multiplying, offering a strategy to fight infections.
CRISPR ‘minigene’ used to prevent genetic liver disease in mice 13 February 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.
