New potential targeted therapy strategy for triple negative breast cancer
A study has shown that targeting the proteins mtp53 and PARP in triple negative breast cancer could inhibit tumour growth and provide a new treatment option.
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Organoids produced to help develop paediatric brain tumour treatments
Scientists have produced hundreds of organoids which they say could be produced on a large-scale as a low-cost tissue model to help research and test new medulloblastoma therapies.
Nanoparticles could be an alternative to antibody immunotherapies
A study has shown that inexpensive nanoparticles can effectively inhibit PD-L1 in cancer cells in the lab and work as well as antibodies, providing a potential alternative immunotherapy.
Inducing factor transforms pluripotent stem cells into totipotent cells
A study has demonstrated that a totipotency-inducing factor can reprogramme stem cells and induce totipotent-like states, possibly increasing their therapeutic potential.
Brain cancer model developed to study glioblastoma
Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.
Molecular motors used to develop bone marrow-derived mesenchymal stem cells
Researchers have used molecular motors powered by UV light to control the growth of bone marrow-derived mesenchymal stem cells.
Inflammatory molecules for controlling capillary loss discovered
Scientists have discovered three major pro-inflammatory mediators that drive capillary loss and identified drug combinations to prevent the degeneration of these tiny blood vessels.
Study shows that lung tumour growth can be reduced by inhibiting p38
A new study has shown that the function of the p38 protein is related to the stimulation of cancer cell division and thus enhances tumour growth.
Research into CDK8 oncogene could improve design of future therapeutics
A study has shown that type II kinase inhibitors targeting CDK8 alone are ineffective because mutations leave them inactive, suggesting future therapies should target CDK8 in complex.
Novel palladium compound shows potent action against treatment resistant cancer cells
Research demonstrated a complex of palladium and thiosemicarbazone is a more selective and powerful chemotherapeutic than the current standard of care cisplatin.
Alternative splicing regulators like AKAP8 prevent cancer metastasis
A study revealed that AKAP8 promotes the alternative splicing of proteins, preventing breast cancer metastasis in animal models and could be the target of future therapies.
Small molecule targeting mRNA could slow the progression of Parkinson’s disease
Research identified a small molecule that targets the mRNA of α-synuclein and prevents the formation of the protein, an approach which could provide novel neurodegeneration therapies.
Cannabinoid screening reveals anti-tumour properties of CBC and CBG
A high-throughput screening test of different cannabinoids has demonstrated that CBC and CBG exhibit anti-tumour effects.
DNA-PK identified as potential targeted therapy for cancer
A study has shown that the sensor of a DNA sensing pathway, DNA-PK, could act as an antiviral against tumours.
Tobacco mosaic virus creates novel malaria vaccine candidate
Researchers in the United States have used particles from the tobacco mosaic virus (TMV) to produce a new much-needed malaria vaccine.