HDAC3 inhibitors: a potential treatment for non-Hodgkin lymphomas?
A murine study found histone deacetylase 3 (HDAC3) inhibitors reverse epigenetic changes caused by CREBBP mutations found in lymphomas and could be developed into a novel therapy.
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Study paves way for new vaccines to protect infants against infections
An mRNA vaccine has been developed which has elicited strong immune responses in mice in the presence of maternal antibodies.
New virus surface characterisation technique developed
Researchers have demonstrated the success of a new single-particle method of studying the surface of viruses, which could improve vaccine purification and the development of gene therapies.
SVC112 molecule reduces effects of cancer stem cells with little toxicity
A study has shown that the SVC112 molecule can prevent cancer stem cells from producing more tumour cells in cell lines and mice, with no impact on healthy cells.
Siah2 protein discovered as a regulator of the immune system
A new study has revealed that the Siah2 protein is crucial to control Tregs in mice, which can reduce the effectiveness of immunotherapies.
Genes found to slow down the development of intestinal tumours
Scientists have found that when two specific genes are deleted in benign tumour tissue in the intestines, it more rapidly develops into a tumour that is more likely to become cancerous.
Universal influenza vaccine protects mice against multiple strains of flu
A new double-layered nanoparticle vaccine protected mice against six strains of the flu and may provide the basis for the first universal vaccine against seasonal influenza, according to research.
Blimp-1 identified as driver of T-cell activity against cancer
A study has shown that T cells are driven to attack tumours by IL-2 and Blimp-1 in mice, which researchers say could form the basis of cancer therapies.
Study identifies drug design applications as main recipient of AI investment
Research suggests that over half of the total $5.2bn investment for artificial intelligence in pharma went to drug design applications in 2019, but overall investment is slowing.
Scientists develop a new way to fight late-stage sepsis
Scientists have used nanotechnology to transform healthy immune cells into a drug with enhanced power to kill bacteria to help the immune system fight sepsis.
Deleting body clock regulator gene BMAL1 protects mice against bacterial pneumonia
Deletion of the BMAL1 gene causes changes to the macrophage cytoskeleton, enhancing mouse model ability to combat bacterial pneumonia infection, according to new research.
ELRIG and British Pharmacological Society enter collaborative alliance
The two organisations have entered into a two-year alliance to improve scientific exchange in the drug discovery industry.
Syndecan-4 cell sensory protrusions activate hallmarks of cancer
A study has revealed that activation of syndecan-4 sensory protrusions extending from cells may be a future target for cancer therapy.
Antibody HIV therapy for primate newborns shows potential as therapy
A study has shown that administering two antibodies soon after birth can prevent HIV from developing in rhesus macaques.
Computational model of molecular interactions could improve new medicine development
Researchers have produced a mathematical framework enabling quick assessment of how different parameters control interactions between molecules with multiple binding sites.