Mapping functional states of oncoproteins with AI
Researchers have developed a computational analysis tool which will improve patient stratification and enable personalised medicine.
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Novel target found for CDKL5 deficiency disorder
Scientists have discovered that increasing the levels of the CDKL2 enzyme could stop CDD symptoms developing or worsening.
Lung adenocarcinoma: metabolic reprogramming of macrophages
Disrupting the mechanism that EGFR-driven lung adenocarcinoma uses to alter macrophages’ lipid metabolism could inspire new treatments.
New therapeutic targets for stress related disorders
A mechanism by which the immune system influences central nervous system function and behaviour has been discovered.
Multi-omic approach classifies biomarkers for paediatric sepsis
Researchers have discovered potential biomarkers to identify paediatric sepsis progression stage, enabling more targeted treatment.
Integrin αV and β5 partner to drive cancer cell growth
A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.
Improving treatments for rheumatoid arthritis patients
Researchers found that resolvinT4 restores protective macrophage biological activities in rheumatoid arthritis patients.
Reducing drug resistance in acute myeloid leukaemia patients
Researchers conducted a proteogenomic characterisation and found that drug exposure changes drug sensitivity.
Organoid drug testing predicts bowel cancer treatment response
A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.
A new machine learning tool identifies drugs to minimise fibrosis
The computer model enables a better understanding of how drugs affect fibroblasts and finds a promising candidate to prevent heart scarring.
How the DA subtype of Wilms tumour resists chemotherapy
Researchers suggest that DA histology slowly emerges by accumulating burdens of DNA damage and copy number aberrations.
Advantages of using cfDNA sequencing for early detection of GDM
A deep learning model developed using circulating cell-free DNA outperformed traditional screening methods for gestational diabetes mellitus.
Regeneration of fully functional urinary bladder tissue
Regenerating bladder tissue with bone marrow stem and progenitor cells gives hope to patients with end-stage bladder dysfunction.
Advancing the understanding of placenta accreta spectrum disorder
A new study has identified targets to refine diagnostic tests, track disease progression, and discover more effective therapies.
Microbiota composition influences respiratory virus susceptibility
The interactions linking intestinal microbiota with the functionality of basally resident alveolar macrophages and severity of infection are revealed.