New screening method identifies potential compounds to combat cancer
The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.
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Study shows that CRISPR-Cas9 gene editing has a low risk of mistakes
A study has shown that unintended mutations from gene editing with CRISPR-Cas9 are rare in zebrafish, providing reassurance that this technology is a valid tool with great promise for the treatment of genetic disorders.
Sartolab® MultiStation
For a hands-free filtration of up to 6 x 50 mL samples in parallel.
Vasomotion revealed as potential strategy to treat Alzheimer’s
A study has demonstrated that inducing brain vessel pulsations helps to clear substances from the brains of mice, so could be used to stop amyloid-β build up in the development of Alzheimer’s.
Scientists discover how strep bacterium hides from the immune system
Produced by Group A Streptococcus, researchers have discovered the S protein, which binds to the red blood cell membrane to avoid being destroyed by immune cells and could be a target for anti-virulence drugs.
Therapeutic target found for diseases caused by lipid accumulation in cells
Researchers have identified the protein Annexin A6 as a potential therapeutical target against diseases that are caused by the accumulation of cholesterol and other lipids in endosomes.
PJ34 triggers self-destruction of human pancreatic cancer cells
A study conducted on human pancreatic tumours transplanted in mice reveals promise for an effective therapy in the future, say researchers.
Researchers must not rely on generic online searches for chemical probes, study finds
The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.
Protein tag developed to aid in study of the immune system
A novel approach to better understand a basic defence mechanism of the immune system has been developed using the ISG15 protein which could lead to novel antimicrobial drugs.
Researchers use imaging to reveal early stages of colon cancer
A study has demonstrated how mutations in early colon cancer prevail and grow into malignancies, using fluorescent imaging.
Direct link shown between inflammasome activation and Alzheimer’s
A new study has demonstrated that NLRP3 inflammasome directly drives tau pathology in neurodegenerative diseases and Alzheimer's disease.
Animal model market set to grow to $24bn by 2025
New research has found that the animal model market for disease research and therapeutic testing will exhibit strong growth.
Novel pathway to target colorectal cancer identified
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
Restarting metabolic process could make sarcoma susceptible to treatment
Researchers have found that soft tissue sarcoma cells stop a key metabolic process which allows them to spread and restarting that process could leave these cancers vulnerable treatments.
Phage-enriched mucosal surfaces could combat bacteria infections
Researchers have found that, in rainbow trout models, phages on mucosal surfaces infect pathogenic bacteria, providing protection.