DNA successfully cut and inserted using Class 1 CRISPR system
A new study has shown that a Class 1 CRISPR gene editing system can achieve functional DNA repairs in human cells with no prominent off-target effects.
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Structure of key pneumonia virus enzyme uncovered
Scientists have used cryo-electron microscopy to clarify the structure of one of the key components of RSV and HMPV, which could lead to new therapies for the viruses.
Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
New class of drugs with potential to fight leukaemia and lymphoma discovered
PROTAC drugs that safely and effectively target leukaemia and lymphoma cells have been developed by researchers.
Mouse model for prostate cancer bone metastasis developed
Researchers have developed a cell line that allows the mechanisms of prostate cancer bone metastasis to be studied in immunocompetent mice.
Method to coax immune system into selecting HIV antibodies developed
Immunogens can be used to coax the immune system into producing broadly neutralising antibodies to fight a HIV infection, making a vaccine against the condition more likely, say researchers.
New method to analyse CRISPR editing developed
Researchers have announced the creation of a novel technique for screening CRISPR edits that allows scientists to identify unintended outcomes in the genome.
Newly engineered peptide shows long-acting efficacy against HIV
Researchers have developed a novel peptide with a prolonged half-life that has demonstrated success in rhesus monkeys and mice for inhibiting HIV infections.
Root of childhood kidney cancer discovered
The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.
New protein function could be key to treatment of drug addiction
Scientists have revealed new findings about the neural circuit involved in the reward stimulus, which plays a major role in drug dependence and psychological disorders.
The Olympus scanR high-content screening station rapidly acquires quantitative data from cell-based assays
Self-learning microscopy opens new horizons in high-content analysis and advances phenotypic screening.
New generation of CAR T cells developed
Researchers have reprogrammed CAR T cells to prevent them becoming exhausted after prolonged activity, presenting a possible new therapy for solid tumours.
New treatment possible to tackle drug-resistant strains of TB
A new discovery could lead to the development of a drug for untreatable strains of TB, which can target uptake of the very amino acid that enables the bacteria to spread within the body.
Cancer immunotherapies may be improved with early immune response
A new mechanism has been reported for detecting foreign material during early immune responses which may help detect elusive cancers.
Two new retinal pigment epithelial cell models developed
Researchers have created two new cellular models that can be used in the study of ocular diseases and drug testing.