Dengue vaccines may be improved by simulating amino acid starvation
Scientists have discovered that a plant-based compound called halofuginone activates a pathway that results in better antibodies and could improve the effectiveness of vaccines.
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Fruit fly model to study mitochondrial diseases developed
Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.
Protein therapeutic development could be accelerated with new method
Scientists have developed a new method that accelerates the design and engineering of potential medicines and vaccines using glycosylation.
Researchers develop vaccine with potential to treat pancreatic cancer
A study has demonstrated that a novel vaccine design for pancreatic cancer has been successful in mice, doubling survival time.
Human heart-in-a-jar model to be developed
Researchers will create the first human heart-in-a-jar to study heart failure, identify new therapeutic targets and test novel treatments.
Fungi library could aid in the search for medical drugs
A library of products derived from more than 10,000 fungi has been established which could lead to the discovery of new drugs.
microRNA could lead to new methods to treat multiple sclerosis
In a pre-clinical model of multiple sclerosis, orally treating susceptible mice with a microRNA from the diseased gut has prevented the disease.
Researchers find mutation in CUL3 gene responsible for autism
Scientists have shown that the mutated CUL3 gene, which is involved in the cell’s clearance of proteins, plays a role in the development of autism and schizophrenia in mice.
MAIT immune cells revealed as key in toxic shock development
Researchers have found that MAIT immune cells respond rapidly to group A streptococcal infection, causing inflammation and toxic shock, which presents a therapeutic target.
New approach to treating incurable leukaemia in children discovered
A new study into the molecular causes of acute lymphoblastic leukaemia could lead to a new target for therapy.
Normal liver cells may have the potential to kill cancer cells
A new discovery that healthy liver tissue surrounding a tumour activates a defence mechanism that restrains tumour growth could inspire new therapeutic approaches that mobilise normal cells to kill cancer cells.
Tendon stem cell discovery could lead to improvements in injury recovery
Researchers have discovered the existence of tendon stem cells, which could lead to improvements in treating tendon injuries, avoiding surgery.
Researchers discover potent new antimicrobial molecule
A compound that has antimicrobial properties has been found by researchers, which could be used to combat drug-resistant infections.
New insights into blood clot mechanisms in cancer patients discovered
A new signalling pathway has been identified that may help further the understanding of blood clot formation in cancer patients and presents a new drug target for reducing cancer-associated complications.
Mucin 6 gene indicates predisposition to late-onset Alzheimer’s
Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.