Fullerene compounds could be effective therapy against NSCLC
Researchers have used fullerene compounds to cause NSCLC cell death in cell and animal models, which exhibited low toxicity for healthy cells.
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Novel therapeutic strategy reverses autism symptoms in mice
Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.
Silencing RNA nanotherapy shows promise in treating pancreatic cancer
Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.
New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
Global consortium formed to combat unproven cell banking services
The International Society for Cell and Gene Therapy has created a group to tackle the rising number of commercial cell bank services that are misleading patients.
LVNC congenital heart condition linked to faulty signalling pathway
A new study, which has shown that the congenital heart condition LVNC could be be caused by signalling defects, may lead to potential therapies.
Collaborative enzyme study could lead to a target for cancer therapeutics
A new study into the enzyme Cdc34 may make it possible to target the enzyme specifically to develop new cancer therapeutics.
Making tumour cells stiff could prevent cancer metastasis
A study has demonstrated that the stiffness of cells indicates whether a tumour will spread and inducing this state could help to avoid metastasis.
Researchers create blastocyst-like models from mouse cells
Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.
Ten genes revealed to contribute to development of schizophrenia
Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.
Study finds astrocytes critical in progression of Huntington’s disease
The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
New drug shows promise as immune therapy for cancers
A therapy has been developed which uses a synthetic RNA molecule developed to fight viruses to trigger an immune response against tumours in mice.
Full gene-replacement model developed for Alzheimer’s MAPT gene research
Researchers in the US have successfully produced a mouse model with a human MAPT gene to enable more accurate research into Alzheimer’s therapy.
Selective inhibitor could reduce resistance to cancer therapies
A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.
Platform may find new options for mental health treatment
A drug discovery platform for mental health treatment could also help to identify mechanisms for the treatment of substance use disorders.