Rhomboid protease role observed using dynamic imaging
Researchers have been able to watch rhomboid proteases in a native lipid environment which may be useful for the development of Parkinson's and malaria medication.
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Microprotein revealed to regulate cell stress by study
Researchers have discovered a microprotein that acts as a regulator of cell stress, which could be used in developing therapies for a wide range of conditions.
New antiviral drug demonstrated to effectively treat influenza in models
A new antiviral drug has been reported in a study that researchers believe has high clinical potential as a next-generation influenza drug.
T cell immune system regulator identified by researchers
A new study has discovered two enzymes which regulate a biological switch that controls the immune system, providing the potential to develop targeted therapies.
New discovery leads to greater understanding of Alzheimer’s disease
A new study has linked an inflammatory protein to impaired memory mechanisms which could lead towards finding a more effective treatment for Alzheimer's.
Polymerised oestrogen shown to protect nervous system cells
Researchers have polymerised oestrogen using a new approach and found it is effective at protecting and regenerating nervous system cells in vitro.
Gene identified in zebrafish effective at repairing heart damage
Researchers have discovered a gene in zebrafish that enables them to successfully recover after cardiac damage, which could be used to repair heart tissues in humans.
Reasons why targeted immuno-oncology drugs sometimes fail discovered
A new study has shown the specific cellular mechanisms that limit the ability of CD8 T cells to infiltrate the tumour microenvironment, which could guide new immunotherapeutic strategies in cancer.
Antibiotics with novel mechanism of action discovered
A new family of synthetic antibiotics that possess broad anti-Gram-negative antimicrobial activity has been discovered.
Machine-learning algorithm developed to aid in epigenetic drug discovery
A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.
Study reveals how circulating tumour cells target organs
Regulator genes and proteins have been identified on circulating tumour cells in mice which allow them to target other organs in the body.
New gene editing tool could correct 89 percent of genetic defects
'Prime editing', a new CRISPR genome-editing approach, is capable of directly editing human cells in an accurate and efficient way.
Fullerene compounds could be effective therapy against NSCLC
Researchers have used fullerene compounds to cause NSCLC cell death in cell and animal models, which exhibited low toxicity for healthy cells.
Novel therapeutic strategy reverses autism symptoms in mice
Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.
Silencing RNA nanotherapy shows promise in treating pancreatic cancer
Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.
