AI designed, synthesised and validated new drug in 46 days
Researchers have developed a new AI system which was able to discover and then successfully test several new compounds within 46 days.
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Key pathway discovered in periodontal ligament maturation
A research team have found a signalling pathway which plays a critical role in the maturation of periodontal ligament, providing information for the development of dental treatments.
Study presents new ways of developing chronic inflammation treatment
Researchers have found a new way to treat the inflammation involved in chronic diseases.
Tuberculosis vaccine shows efficacy in pre-clinical trials
Australian researchers have demonstrated the success of a novel TB vaccine in mice, which could provide another treatment option for the disease.
Breast cancer ‘sleeper cells’ could be formed after drug treatment
Breast cancer medicines may force some cancer cells into 'sleeper mode', allowing them to potentially come back to life after treatment.
Membrane protein function behind epilepsy discovered
Researchers have revealed the 3D structure of a membrane protein which plays a role in the development of conditions such as epilepsy and blindness.
New treatments for liver disease could be identified with lab-on-a-chip
New lab on a chip technology has been developed to evaluate the effects of different drivers of NAFLD on liver cells.
Researchers reverse obesity in mice using CRISPR-Cas9
A study has used CRISPR-Cas9 to treat obesity and type 2 diabetes symptoms in mice, highlighting the potential use in humans.
Gut microbiota in patients with sepsis linked to organ damage
The gut microbiota has been linked to organ damage in patients with sepsis suggesting targeting intestinal microbiota may help patients' recovery.
Muscular dystrophy mutation shown to protect against HIV-1
Researchers have discovered that a rare muscle disease causes resistance to HIV-1 infection in patients, providing insight into potential therapies.
Stem cell division in the geriatric brain blocked by signal
It has been discovered that Id4 controls whether stem cells enter cell division and may be relevant for treating neurodegenerative disease.
Structure of crucial metabolic enzyme revealed by high-end microscopy
Scientists reveal the atomic structure and regulative mechanism of the metabolic enzyme transhydrogenase.
Blocking kinase could provide treatment for prostate cancer
Researchers have found that inhibiting a kinase in mice leads to the death of prostate cancer cells, providing a potential therapeutic target.
Study identifies molecule key in leukaemia treatment resistance
Researchers have found a molecule, which when deleted, increases leukaemia sensitivity to natural killer cells and is a drug target.
Scientists develop retina-on-a-chip to study eye diseases
Combining organoid and organ-on-a-chip technologies, researchers have created a model which will allow them to study eye diseases and treatments for the retina.