MicroRNA regulates drug tolerance in subset of lung cancers
Newly identified pathway offers promising targets for preventing tumour relapse...
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New DNA ‘shredder’ technique goes beyond CRISPR’s scissors
A new CRISPR-based tool that acts more like a shredder is able to wipe out long stretches of DNA in human cells with programmable targeting...
Zebrafish reveal insights into Parkinson’s
The findings offer clues that could one day lead to treatments for the neurological condition...
Cancer vaccine shows promising results in Lynch syndrome
Vaccination with as few as four tumour antigens generated antigen-specific responses, reduced intestinal tumours, and improved survival in a mouse model of Lynch syndrome...
HER2-targeted CAR T-cell therapy shows promise in patients with sarcoma
A combination of chemotherapy and chimeric antigen receptor (CAR) T cells designed to target the protein HER2 was found to be safe and showed clinical responses in paediatric and adult patients with advanced HER2-positive sarcoma...
Scientists decipher 3D structure of promising molecular target for cancer treatment
Columbia University discovery could be a major step in developing therapies for cancer, controlling cholesterol...
Gut microbiome directs immune system to fight cancer
The advent of immune checkpoint inhibitors is a major breakthrough in cancer immunotherapy...
Creating blood vessels on demand
A new study shows that stable angiogenesis can be achieved by simply injecting a hydrogel with mechanical properties resembling that of a blood clot...
New target for chronic pain relief
Scientists observe drug target that can reduce pain when activated...
Therapeutic strategy to prevent gastrointestinal disease
New approach restores epithelial function in diarrhoea and inflammatory bowel disease models...
Computational method enhances drug target stability
Scientists have developed a new computational method for the design of thermally stable G protein-coupled receptors (GPCRs) that are of great help in creating new drugs...
New technology to produce dorsal cortical neurons using iPS
Scientists expect that it will soon be possible to treat brain diseases by restoring damaged areas in the brain by mass producing neurons using stem cells...
New mass spectrometry system for finding potential drugs
New method for computational mass spectrometry will speed up the discovery of natural products that could be used in medicines...
Heating up tumours could make CAR T therapy more effective
When a heating technique called photothermal ablation was combined with the infusion of CAR T cells, it suppressed melanoma tumour growth for up to 20 days in mice...
Scientists home in on microRNA processing for cancer therapies
Research on the mda-7/IL-24 gene has shown that it helps to suppress a majority of cancer types, and now scientists are focusing on how the gene drives this process by influencing microRNAs...