New cell culture model reveals neurodegeneration mechanisms
Researchers discovered that NPTX2 protein accumulated in cells containing abnormal TDP-43 in FTD and ALS patients.
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DOP-targeted therapies could exert significant anxiolytic effects
Researchers have uncovered the role of the PL-BLA neuronal axis and its potential function in DOP-mediated anxiolytic effects.
Using omic data to develop and validate biomarkers of ageing
Researchers highlight the need for considering biomarkers alongside other health outcomes, as well as the need for omic data standardisation.
A promising new treatment strategy for hepatoblastoma
A combination therapy of vincristine, irinotecan and panobinostat, tested in high-risk, relapsed or refractory HB spheroids, decreased tumour marker levels.
Combatting HIV using gene therapy
Researchers have created a nanomedicine loaded with siRNAs, which demonstrated a 73 percent reduction in HIV replication.
4PY found to directly trigger vascular inflammation
Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.
Potential new therapies for primary open-angle glaucoma
Researchers have gained a better understanding of the genes and biological processes that could influence POAG pathogenesis.
Mitigating oxidative stress in neurodegenerative diseases
Researchers have found that using protein-like polymers to inhibit the Keap1/Nrf2 PPI is a powerful therapeutic strategy.
The molecular mechanisms of lenacapavir revealed
Researchers discover a mechanism that could be exploited for targeting other viruses that build capsids to hide from host defences.
New antibiotic overcomes antimicrobial mechanisms
Researchers have created a novel molecule, which has an improved ability to bind to bacterial ribosomes, with a completely synthetic system.
Identification of an immune biomarker for liver cancer
New immunotherapies may be developed for patients with HCC associated with steatotic liver disease, with TREM1 suggested as a target.
Uncovering the bidirectional relationship between PD and DM
Single-cell RNA analysis provides an immunological explanation for the association between periodontitis and diabetes mellitus.
SPOCD1 and C19ORF84: insights into severe male infertility
Researchers have discovered the role of two genes that protect mammalian germ cells, which could influence male fertility.
The implications of EN-1 overexpression in late-stage PDAC
Using tumour organoids, researchers identified that overexpression of Engrailed-1 blocked genes associated with natural cell death.
Oxytocin could mitigate the progression of dementia
For the first time, researchers reveal the involvement of OXT in object recognition memory through the supramammillary nucleus.
