Single enzyme provides target for new sepsis drugs
Researchers have discovered that removing the enzyme, PHLPP1, improves outcomes in a mouse model of sepsis so could be a potential drug target.
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Blood-brain barrier role in Alzheimer’s patients revealed by tissue model
A new study has found that damage caused by Alzheimer's allows toxins to enter the brain, further harming neurons.
Parkinson’s disease symptoms “improved” by oestrogen
New research into sex-based differences of Parkinson's disease could lead to new treatments.
Study identifies virulence factors of Leishmania
Researchers have discovered the mechanism behind the spread of Leishmania, indicating a potential drug target.
Molecule identified as key in pancreatic cancer metastasis
New findings show that the environment for pancreatic cancers plays a role in its metastasis, revealing a new potential drug target.
Direct toxic action of beta-amyloid in Alzheimer’s patients identified
The cause and trigger of the large clumps of protein beta-amyloid found in the brains of early-stage Alzheimer's patients have been discovered.
Four cell types discovered in glioblastoma tumours
A new study has revealed that glioblastomas contain four different types of cell which the researchers say should be treated separately.
Experimental compound could be used to treat pancreatic cancer
Using a compound called PTC596 in combination with other drugs, researchers effectively treated pancreatic cancer in mice.
Therapeutic target for Kennedy’s disease and prostate cancer proposed
A chaperone protein has been identified as a possible therapeutic target for the treatment of Kennedy's disease and prostate cancer.
Potential treatment target identified for Crohn’s disease
Researchers have identified a pathway in the immune system activated in Crohn's disease which could lead to investigating new treatments.
Interferon pathway could provide drug target for cancers
A study has found that signals from interferons can be blocked, allowing the immune system to attack tumours which provides a potential target.
CRISPR-Cas used to edit cystic fibrosis gene mutations
A research team have used genome editing to correct two of the mutations that cause cystic fibrosis.
Industry objects to unproven T-cell preservation services
The ISCT is objecting linking the benefits of cellular immunotherapy with third party offerings of T-cell banking for future therapeutics.
Novel nano-vaccine for melanoma developed
A novel nano-vaccine has been developed which has proven effective in treating primary tumours and metastases that result from melanoma.
New drug could be used for targeted cancer therapies
A new drug called IP1867B, which could be used for future treatments of brain tumours, is being examined.
