Macrophage phenotype insights could improve immunotherapy
A certain macrophage phenotype is more effective than another phenotype commonly used in cell therapy for infiltrating tumours.
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Incorporating microglia into brain organoids
iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.
Enzyme-activated fluorescent probes could revolutionise healthcare
Advancements in enzyme-activated near-infrared fluorescent probes hold promise for evaluating responses to enzyme-targeting therapies.
Biomarkers found in the temporary regression of type 1 diabetes
The partial remission phase of type 1 diabetes, in which residual β-cells recover insulin production, offers new hope for therapeutic action.
Breast cancer cells invade by a physical mechanism
Findings from using a 3D hydrogel to study how cancer cells physically tear the basement membrane offers promise for targeted treatment.
Targeting senescent macrophages: a potential cancer treatment
Using the nicotinamide mononucleotide molecule led to proliferation of non-senescent macrophages and lessened immunosuppressive factors.
Rare genetic variant blocks common Alzheimer’s disease risk factor
New understanding of “Christchurch mutation” in the APOE gene may lead to novel Alzheimer's disease treatments.
Improving ovarian cancer outcomes with artificial intelligence
Researchers have developed an AI based model that is 80 percent accurate in predicting the therapy outcome of high-grade ovarian cancer.
Cancer and the DNA fork reversal mechanism
Researchers find that polymerase epsilon exonuclease is an essential target for cancer diagnosis and treatments that rely on DNA damage.
Essential role of Nrg1 in heart development
New research identifies how trabeculae transform into ventricles, which could positively impact heart disease treatments.
New bacterial protein found to improve mitochondrial function
Protein released by C. burnetti interacts with antioxidising enzyme GPX4 to prevent cell damage and death.
Potential for improved rheumatoid arthritis treatment
Six types of inflammation with various cell types and disease pathways identified may provide better treatment of rheumatoid arthritis.
Huntington’s disease: danger of repeated DNA sequences
Scientists find a way to slow the progression of Huntington’s disease by analysing DNA and find the basis of a potential treatment.
New technique to extract and analyse extracellular vesicles
Cellulose nanofiber sheets enable analysis of EVs, and miRNAs within them, offering potential for cancer treatment and personalised medicine.
How glucose restriction causes aggressive lung cancer phenotype
New understanding of how lung cancer cells become more aggressive when nutrient deprived could lead to novel combination treatments.