How pathological alpha synuclein causes neuron death
A new finding that pathological alpha-synuclein causes cells to increase protein synthesis suggests new targets for treating PD.
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AI system produces binding proteins using limited target information
New software can make protein molecules that bind with high affinity and specificity to many biomarkers, including human hormones.
Disrupting the mechanism pathogens use to infect host cells
New understanding of the communication system between pathogens and host cells provides a way to avoid antimicrobial resistance.
Improved targeted ocular spectroscopy for better diagnosis
In vitro and in vivo experiments highlight the advantages of a new targeted spectroscopy system for many eye diseases.
The influence of the immune system on early human lung growth
Understanding the mechanisms in lung formation could develop new therapeutic approaches for respiratory conditions.
HIV vaccine may require a strong response from CD8+ T cells
The new findings could help preventive and therapeutic HIV vaccine design and development, and HIV immunotherapy approaches.
Novel AI algorithm improves decoding accuracy of brain signals
A new deep-learning method could enhance therapeutic devices for people with neurological or mental health conditions.
Potential target found for CDKL5 deficiency disorder
Using phosphoproteomics, the calcium channel Cav2.3 was found as a target to treat a type of genetic epilepsy, CDKL5 deficiency disorder.
New lipid nanoparticles effectively deliver RNA to microglia
LNPs deliver small interfering RNA to the brain’s microglia to combat inflammation related to Alzheimer’s disease.
New method to induce target-specific immune responses
By fusing antigen proteins into an anchor protein, a specific disease could be targeted without the need to purify the antigen.
Perivascular fibroblasts support glioblastoma tumours
Glioblastomas can resist immunotherapy as perivascular fibroblasts support the creation of an immunosuppressive tumour environment.
New organoid model of neuroendocrine tumours developed
NETs require epidermal growth factor to grow, meaning that inhibiting EGF receptors could treat these types of tumours.
Potential therapeutic target found for the Zika virus
A discovery about Zika’s enzyme, NS2B-NS3, offers promise for therapeutic targets for Zika and other flaviviruses.
Potential small molecule drug could treat multiple sclerosis
The new small molecule targets the glutamate system, reducing MS-like symptoms and repairing damaged myelin in two different animal models.
Astrocytes gain neural stem cell properties after brain injury
Astrocyte plasticity is correlated with upregulation of the Galectin 3 protein, which may greatly contribute to biomarker discovery.