Effective approach to optimising medicinal molecules
Computational methods accelerates and automates the process of optimisation of candidate molecules before performing preclinical trials...
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IgG3 antibody can block B cells from fighting pathogens during HIV infection
Scientists have shown that in certain people living with HIV, a type of antibody called immunoglobulin G3 stops the immune system's B cells from doing their normal job of fighting pathogens...
Targeting the growth signals of ‘undruggable’ cancers
Dr Bivona and his team showed that the growth of multiple cancers slowed by suppressing the signalling pathway using an experimental compound...
Genetic model predicts risk for common deadly diseases
Using data collected from the UK, the data suggests that up to 25 million people in the US may be at more than triple the risk of coronary artery disease...
Combination therapy may be useful against resistant bacteria
The team found that colistin worked well with protein synthesis inhibitor antibiotics, which alone have no activity against Gram-negative bacteria...
Genetic tools uncover cause of early infantile epileptic encephalopathy
Researchers have developed high-tech tools to uncover the genetic cause of the most difficult to diagnose cases...
Injecting VIP into the eye improves corneal transplant survival
Results using mouse models suggest that vasoactive intestinal peptide may provide a new method of improving the outcomes of corneal transplant surgery...
Global NGS market report 2018-2024
The main areas identified to hinder NGS market growth are the lack of skilled professionals and complications relating to data storage...
Scientists counter epigenetic reprogramming for ischemic cardiomyopathy patients
Congestive heart failure is a terminal disease that affects nearly 6 million people in the U.S.; yet its management is limited to symptomatic treatments as its causal mechanisms – including its most common form, ischemic cardiomyopathy – are unknown.
Autoimmune response drives vision loss in glaucoma
New research shows that immune cells developed from early exposure to bacteria contribute to vision loss in glaucoma patients...
Drugs in development for cancer may also fight brain diseases
PARP inhibitors show promise in preventing toxic accumulations of brain disease proteins in Penn research study...
Potential indicator for the early detection of dementias
A team of neuropathologists worked together to show that the impairments affecting mitochondria also affect neighbouring organelles...
Novel vaccine approach proves powerful against Zika virus
VSV acted as a vehicle to deliver the genes of some proteins from the Zika virus into mouse models, leading to immunity build up in the mice...
Genes increasing the risk of triple-negative breast cancer identified
Germ line genetic testing analyses blood samples and evaluates inherited genetic changes that increase the risk of certain cancers in an individual...
Reducing NOVA1 helps prevent tumour growth in lung cancer
Researchers have identified a gene that when inhibited, reduced human non-small cell lung cancer tumours from growing...