AI system designs drugs from scratch
An artificial-intelligence approach created can teach itself to design new drug molecules from scratch and has the potential to dramatically accelerate the design of new drug candidates...
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Research into cellular signalling mechanisms may lead to new treatments
Wnt moves to specific areas of the cell membrane, interacting with a receptor known as Ror2, and inducing the formation of a cytoneme...
Novel antibiotics can be found on common weeds
The team studied chemical compositions in detail and from one strain of bacteria several antibiotically active chemical substances were discovered...
IKZF1 gene could improve cancer immunotherapy
A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy...
CBD improves survival rates of mice with pancreatic cancer
Mice with pancreatic cancer that were treated with CBD alongside chemotherapy, survived almost three times longer than those treated with chemotherapy alone...
Susceptible genes for childhood nephrotic syndrome identified
A specific haplotype was identified as having the highest risk of development, with another showing the lowest risk...
New ligand binding site identified through computer simulations
Many therapeutic compounds target GPCRs and so new ligand binding sites can help to design drugs more efficient at targeting GPCR...
CMPK2 inhibitor could lesson symptoms of common illnesses
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
UBR5 protein may reduce neurodegeneration in Huntington’s disease
Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...
New drug for ALS ready for clinical trials
Previous studies have suggested that a gene therapy drug may be used to treat ALS...
BCX7353 shows hope for hereditary angioedema
A new drug has been developed to help prevent attacks of hereditary angioedema and at the same offer patients a convenient administration...
Blood test predicts the best treatment for prostrate cancer
The study showed that patients testing positive for AR-V7 responded better to taxane-based chemotherapy and negative to hormone-targeted therapy...
Researchers identify new arthritis severity gene
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by...
Study suggests viral connection to Alzheimer’s disease
A first-of-its-kind study implicates another culprit in the path to Alzheimer's disease: the presence of viruses in the brain...
Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...