CRISPR-Gold used to reduce repetitive behaviours in FXS
Gold nanoparticles carried Cas9 enzyme into brain, editing receptor and lessening burying behaviour...
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Researchers reveal therapeutic target for Influenza A
Researchers show altering the molecular interactions between the flu virus and host genes stunts virus replication...
NIH-funded study finds new evidence that viruses may play a role in Alzheimer’s disease
Analysis of large data sets from post-mortem brain samples of people with and without Alzheimer's disease has revealed new evidence that viral species, particularly herpesviruses, may have a role in Alzheimer’s disease biology.
Bioactivity profiling supporting the progression of phenotypic hits
Addressing the optimisation of hits derived from a target-agnostic phenotypic screen, using a strategy based on combining bioactivity profiling and reference compound characterisation...
Researchers uncover new target to stop cancer growth
Researchers have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes that stimulate tumour progression...
Human immune ‘trigger’ map paves way for better treatments
A discovery about how human cells are 'triggered' to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders...
Molecular alterations provide insight into Huntington’s disease
Scientists have applied their high-throughput, multi-pronged approach to Huntington's disease, and uncovered the functional significance of various molecular changes...
ATP1A3 gene mutations associated with infantile forms of schizophrenia
Scientists have identified novel genes associated with a specific form of schizophrenia the discovery will aid diagnosis and development of treatments...
Mini-ecosystems developed to test a molecules therapeutic effect
Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'mini-ecosystems to quickly see if a molecule can function as a potential therapeutic...
Gene signature holds promise for early detection of active TB
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin.
Breast cancer could be prevented by targeting epigenetic proteins
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone.
RNA-Seq assay can detect gene fusions in solid tumour cells
Using the RNA-Seq assay to detect gene fusions can improve the diagnosis and targeted treatment of solid tumors, reports The Journal of Molecular Diagnostics
Microglia protect sensory cells needed for vision after retinal detachment
New research shows that microglia, immune cells of the brain and retina, play a protective role in response to retinal detachment...
CRISPR technology may improve accuracy of predicting heart disease risk
Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...
Targeting BAFF reduces the development of atherosclerosis
The researchers identified that BAFF to have anti-inflammatory properties, which has a positive effect on plaque size and atherosclerosis...