Autoimmune response drives vision loss in glaucoma 10 August 2018 | By Drug Target Review New research shows that immune cells developed from early exposure to bacteria contribute to vision loss in glaucoma patients...
Drugs in development for cancer may also fight brain diseases 9 August 2018 | By Drug Target Review PARP inhibitors show promise in preventing toxic accumulations of brain disease proteins in Penn research study...
Potential indicator for the early detection of dementias 9 August 2018 | By Drug Target Review A team of neuropathologists worked together to show that the impairments affecting mitochondria also affect neighbouring organelles...
Novel vaccine approach proves powerful against Zika virus 9 August 2018 | By Drug Target Review VSV acted as a vehicle to deliver the genes of some proteins from the Zika virus into mouse models, leading to immunity build up in the mice...
Genes increasing the risk of triple-negative breast cancer identified 8 August 2018 | By Drug Target Review Germ line genetic testing analyses blood samples and evaluates inherited genetic changes that increase the risk of certain cancers in an individual...
Reducing NOVA1 helps prevent tumour growth in lung cancer 8 August 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have identified a gene that when inhibited, reduced human non-small cell lung cancer tumours from growing...
‘Drug cocktails’ could strengthen targeted cancer therapies 7 August 2018 | By Drug Target Review "Targeted therapies have revolutionised cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy..."
New drugs targeting gut microbes may reduce the risk of cardiovascular disease 7 August 2018 | By Drug Target Review The new class of drugs are mechanism-based inhibitors which potentially interrupt the gut microbial pathway that produces TMAO...
CRISPR-Cas9 used to correct sickle cell–causing mutation 7 August 2018 | By Dr Zara Kassam (Drug Target Review) Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...
Novel PET imaging could guide therapy for type 1 diabetes 6 August 2018 | By Drug Target Review Since beta cells and neurological tissues have common receptors, researchers screened brain radioligands for their ability to identify beta cells...
pH imbalance in astrocytes may lead to Alzheimer’s disease 6 August 2018 | By Drug Target Review The researchers found that 10 of the 100 most frequently down-regulated genes were connected with proton flow in the cell...
BDNF protein could be key to preserving heart function in DMD 6 August 2018 | By Drug Target Review A protein known to drive nerve cell survival in the brain and spinal cord may also protect failing hearts in children and young adults with DMD...
Aortic plaques may contribute to liver disease progression 3 August 2018 | By Drug Target Review Aortic atherosclerotic plaque inflammation may contribute to the progression of non-alcoholic fatty liver disease to liver fibrosis...
miR-132 offers hope for novel Alzheimer’s treatments 3 August 2018 | By Dr Zara Kassam (Drug Target Review) The study of neuroprotective microRNAs like miR-132 may lead to new avenues for treating Alzheimer's disease and other tau pathologies...
Cas12a enzyme could make CRISPR gene-editing more effective 2 August 2018 | By Dr Zara Kassam (Drug Target Review) Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...
