Preventing exhaustion in immune cells boosts immunotherapy in mice
Research shows that preventing or reversing ‘T-cell exhaustion’ with targeted therapies could enhance the effects of immunotherapy.
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Paediatric Clinical Trials
When designing a Paediatric clinical trial, a paediatric investigation plan (PIP) is a development plan aimed at ensuring that the necessary data are obtained through studies in children, to support the authorisation of a medicine for children...
Splicing-variant detection method identifies biomarkers for HCC
Researchers report a method for identifying splicing-based biomarkers for hepatocellular carcinoma....
Blockade of MT4-MMP protease increases blood-patrolling monocyte activity
Researchers in Spain have identified a function of the MT4-MMP protease (an enzyme that breaks down proteins) that could be targeted as a potential treatment for some infections, as well as tumour metastasis.
Scientists create complex transmembrane proteins from scratch
Advance paves the way for the design of transmembrane proteins with useful new functions...
Change in neuron size could shed light on new treatments for ALS
Understanding how motor nerve cells respond to motor neurone disease could help researchers identify new treatment options...
Researchers find transferable antibiotic resistance gene in pathogen of developing nations
A team of investigators has found that the mcr-1 drug resistance gene, which encodes resistance to a drug that is used as a last resort, has been found for the first time in Shigella flexneri.
Scientists advocate less toxic treatment for rare leukaemia (MPAL)
Researchers in the US have undertaken meta-analysis studies to ascertain the optimum approach for doctors treating rare mixed phenotype acute leukaemia (MPAL). They found that a less-toxic regimen gives better results.
Scientists find that dectin-1 receptor protects against allergies
Contrary to previous notions that the receptor dectin-1 causes allergic reactions, new research from the John Hopkins Bloomberg School of Public Health has found that it actually prevents this response, indicating new targets for allergy and asthma drugs.
Staphylococcus epidermidis may protect against skin cancer
Researchers have reported a potential new role for some bacteria on the skin, protecting against cancer...
Six leading pharma firms to participate at Pharmaceutical Microbiology event in San Diego
SMi’s 2nd Annual Pharmaceutical Microbiology West Coast Conference will be taking place in San Diego, USA on the 7th - 8th June 2018.
Scientists identify new stem cell that helps regenerate lung tissue after trauma
Researchers from the University of Pennsylvania have identified a lung stem cell that repairs the organ's gas exchange compartment, providing potential new approach to treat lung disease.
Pancreatic stem cells have potential to regenerate beta cells
Findings pave way for regenerative cell therapies in type 1 diabetes patients...
Researchers evaluate tau phosphorylation related targets for Alzheimer’s research
Scientists in Moscow have extended the reach of QSP modelling by applying it to tau phosphorylation to better understand Alzheimer’s disease (AD) progression.
Pro72Arg gene variant increases tumour cell metabolism
Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...