Adaptive Designs in Clinical Trials 2018
In its 10th year, the Adaptive Designs in Clinical Trials conference returns to central London in April 2018...
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News
CRISPR-based system identifies drug targets in AML
Scientists have discovered a way to rein in an overactive protein that drives some aggressive leukaemias...
CRISPR/Cas9 technique suppresses malaria infection in mosquitos
Genome editing could enable new strategies to prevent malaria transmission to humans...
Imaging agent helps predict success of lung cancer therapy
Doctors may soon be able to predict the efficacy of a widely used lung cancer drug based on an imaging agent and a simple scan.
Helmintex assay detects low intensity schistosomiasis infections
Individuals who release low numbers of schistosome eggs in their faeces may now use the Helmintex method-- which uses a magnetic field to isolate eggs to detect infections...
Controlling ceramides could help treat lipotoxic cardiomyopathy
Study of Drosophila links ceramide accumulation to heart dysfunction...
Combination therapy suppresses HIV-like virus in primates
Broadly neutralising antibody treatment may target viral reservoir in monkeys...
Scientists develop novel method for membrane protein crystallisation
Scientists in Switzerland have developed a new means of crystallising membrane proteins – a hitherto elusive feat – in order to study their structure and aid understanding of their processes.
Researchers create enhanced nanoscaffold for regenerative heart medicine
Biophysicists in Russia have gained greater understanding about the structure of nanofibrous scaffolds – termed nanoscaffolds – in a study that is researching heart tissue regeneration.
Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
EGFL7 protein provides a new treatment approach for MS
Researchers have discovered that the EGFL7 protein inhibits the migration of immune cells into the brain...
Preventing exhaustion in immune cells boosts immunotherapy in mice
Research shows that preventing or reversing ‘T-cell exhaustion’ with targeted therapies could enhance the effects of immunotherapy.
Paediatric Clinical Trials
When designing a Paediatric clinical trial, a paediatric investigation plan (PIP) is a development plan aimed at ensuring that the necessary data are obtained through studies in children, to support the authorisation of a medicine for children...
Splicing-variant detection method identifies biomarkers for HCC
Researchers report a method for identifying splicing-based biomarkers for hepatocellular carcinoma....
Blockade of MT4-MMP protease increases blood-patrolling monocyte activity
Researchers in Spain have identified a function of the MT4-MMP protease (an enzyme that breaks down proteins) that could be targeted as a potential treatment for some infections, as well as tumour metastasis.