Study suggests PD-1 inhibitors against aggressive pediatric brain cancer subtype
A study has laid the groundwork for the use of PD-1 inhibitors with an aggressive form of brain cancer, namely supratentorial pediatric ependymoma.
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Gimap5 gene mutations found to trigger immune diseases
Scientists discovered how a gene mutation affects T cell function to promote immune disorders...
Novel curative gene therapy treatment for pulmonary fibrosis in mice
Researchers in Spain have developed a method of gene therapy that cures pulmonary fibrosis in mice by lengthening telomeres – the protective protein sections at the end of chromosomes.
Mirror-image peptides of existing drugs provide longer-lasting therapeutic effects
Researchers have developed a new technology for creating more durable disease-fighting molecules which could lead to drugs with longer-lasting effects...
Sirt2 enzyme identified as therapeutic target for diabetes
Researchers have identified the sirtuin enzyme as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting a potential therapeutic target for type 2 diabetes...
GalNAc-T6 enzyme selectively up-regulated in colon adenocarcinomas
Researchers have identified an enzyme that appears to drive the conversion of normal colon tissue into cancer...
Uncovering the early origins of Huntington’s disease using CRISPR engineered embryonic stem cells
Researchers have developed a system to model Huntington's in human embryonic stem cells...
ZNF274 deletion reverses Prader-Willi syndrome
Reversing the imprinting that causes Prader-Willi syndrome gives hope that epigenetic diseases can be cured...
DRD2 crystal structure provides antipsychotic drug development tool
Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...
Elimination of c-Raf kinase induces regression of advanced lung tumours
A study has shown how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours...
Statistical computing tool visualises employment trends in biomedical science
Scientists looking for jobs after completing their training may soon have a new tool that helps them evaluate various career paths...
MSK1 protein keeps metastatic breast cancer cells dormant
A study has identified the genes involved in the latent asymptomatic state of breast cancer metastases...
Systemic clearing of senescent astrocytes presents new therapeutic avenue for Parkinson’s disease
Researchers illuminate a new focal area for Parkinson’s disease therapy after demonstrating the beneficial effects of systemic clearing of senescent astrocytes.
Researchers uncover the origins of leprosy and reason for its drug resistance
Scientists in Switzerland have developed the tools to sequence genes from the leprosy bacterium, Mycobacterium leprae, revealing information about its origins and reasons behind its resistance to drugs.
Blocking 20-HETE chemical counters the siren call of aggressive cancers
Scientists have successfully blocked the powerful call of two types of aggressive cancer – glioblastoma and breast cancer – in laboratory models; with evidence that inhibiting the chemical 20-HETE halts tumour growth.
