New algorithm identifies a novel CRISPR-Cas system
Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.
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Potential of small molecule therapeutics for Barth syndrome
Novel findings about the tafazzin gene offers a potential new target and drug candidate for Barth syndrome.
Noncoding RNA could be a new target for acute myeloid leukaemia
Discovery about the DNA of leukaemia cells suggests promising target for gene therapy in paediatric oncology.
Genetically engineered transplants avoid immune rejection
Researchers have found a way to genetically modify stem cells so that cell and organ transplants are not rejected.
Target found for pulmonary hypertension treatment
An epigenetic pathway is mediated by a certain protein that could potentially reverse vascular remodelling in pulmonary hypertension.
Engineered biofilm helps to tackle infections in CF patients
A living material resembling sputum from CF patients can grow biofilms, enabling scientists to assess the effectiveness of antimicrobials.
Nano-sized traps enable better study of proteins
Researchers have developed a new method to study protein clumps that occur in many difficult-to-treat diseases.
New colon organoids better resemble both healthy and diseased colons
Researchers have developed organoids with naturally occurring early-stage immune cells, which could lead to effective personalised treatment.
Improving treatment response to KRAS inhibitors
Eliminating AT1-like cells in experimental models has shown potential to improve KRAS inhibitor treatment for lung adenocarcinoma.
Promising strategy for glaucoma cell replacement therapy
Changing blood stem cells into retinal ganglion cells that can migrate to the eye’s retina offers hope for cell replacement therapy.
Ribosomes repair damage to single stranded RNA
Crosslinking damage to single stranded RNA, caused by aldehydes, is repaired by newly discovered mechanism involving ribosomes.
Macrophage phenotype insights could improve immunotherapy
A certain macrophage phenotype is more effective than another phenotype commonly used in cell therapy for infiltrating tumours.
Incorporating microglia into brain organoids
iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.
Enzyme-activated fluorescent probes could revolutionise healthcare
Advancements in enzyme-activated near-infrared fluorescent probes hold promise for evaluating responses to enzyme-targeting therapies.
Biomarkers found in the temporary regression of type 1 diabetes
The partial remission phase of type 1 diabetes, in which residual β-cells recover insulin production, offers new hope for therapeutic action.