DNA-based Zika vaccine found effective at inducing immune response
A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...
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E6/Myc binding provides potential treatment strategy for HPV
A study that teases apart the biological mechanisms by which HPV cause cancer, has found a strategy that may provide targeted treatment...
NRF2 pathway provides new approach to cancer drug discovery
Scientists have developed a promising new strategy for the discovery of novel anti-cancer therapies for non-small-cell lung cancers...
Metabolic collaboration linked to Alzheimer’s disease
Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration...
Scientists develop broad-spectrum inhibitors of influenza virus
Scientists have developed broad-spectrum inhibitors of the influenza virus using artificial peptide molecules...
Novartis and UC Berkeley collaborate to tackle ‘undruggable’ disease targets
Collaboration aims to unlock difficult drug targets and accelerate the discovery of new medicines in areas such as infectious diseases and cancer...
CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer
Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...
Parkinson’s UK Drug Discovery Manager joins DTR advisory board
Drug Target Review welcomes Janusz Kulagowski to its advisory board ...
Influenza viruses can help mutated viral proteins fold and function
A new study from has shed light on just how viruses evolve so quickly and offers a potential way to slow them down...
CYC065-eribulin combination therapy for triple-negative breast cancer identified
Researchers find novel combination disrupts multiple factors in aggressive breast cancer...
CCL11 may allow early CTE diagnosis
Researchers have identified a new biomarker for chronic traumatic encephalopathy that may allow the disease to be diagnosed during life for the first time...
Streamlined process opens drug development to a new class of steroids
Researchers have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries...
Potential therapeutic protein inhibitors for Chagas disease
Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...
MMP20 gene variants linked to high-risk childhood cancers
Paediatric researchers have identified common gene variants that raise the risk of an aggressive forms of childhood cancer...
National Physical Laboratory re-launched to improve access to health innovations
NPL's new approach informed by government priorities, consultancy with industry and the NHS, and a century of expertise, will see it focus on some of the world’s biggest health challenges, from supporting the diagnosis and treatment of cancer and dementia, to reducing attrition rates in drug development, to creating new…