Spread of tau protein measured in the brains of Alzheimer’s patients
In a new study researchers measured how deposits of the pathological protein tau spread through the brain over the course of Alzheimer’s disease.
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Preclinical candidate CGRP antagonist has potential as treatment for migraines
A preclinical candidate calcitonin gene-related peptide (CGRP) antagonist has been nominated for advancement into further preclinical studies as an investigational treatment for migraine.
Control mechanism unveiled for gene that causes Opitz syndrome
Opitz G/BBB (Opitz) syndrome is a hereditary disorder that affects people in different ways, causing malformations in medial (midline) organs and structures, intellectual disability and developmental disorders.
Anticancer nanomaterials created by simulating underwater volcanoes
Researchers at Aalto University, Finland, have developed anticancer nanomaterials by simulating the volcano-induced dynamic chemistry of the deep ocean.
New gene variant identified in ALS provides treatment hope
A new study shows that a variant in UBQLN4 gene has been associated with Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS). The study also describes how this gene variant disrupts a cellular process that drives motor neuron development. This new insight opens the door to potential treatment targets for…
New CDC-funded portal to schedule free colon cancer screenings
Illinois Colon CARES, a University of Chicago Medicine-led initiative, seeks to become model for other states to increase access for vulnerable populations…
New counterintuitive approach to treating brain cancer
The loss of the tumour suppressor gene PTEN has been linked to tumour growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM).
Researchers find key molecule that could lead to new anaemia therapies
Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.
Charles River Laboratories announces updates to oncology business
Charles River Laboratories International, Inc. (NYSE: CRL) recently announced updates to its expanding oncology discovery business, including significant additions to its online Tumor Model Compendium...
New targeted approach for epilepsy drug therapies
New research from the University of Liverpool, in collaboration with the Mario Negri Institute in Milan, has identified a protein that could help patients with epilepsy respond more positively to drug therapies.
Assay of clotting ability accurately predicts need for transfusion in trauma patients
A new test of blood clot strength has the potential to identify patients who are most in need of a substantial blood transfusion.
Collaborations in early drug discovery
The earliest phases of drug discovery used to be confined to research divisions of large pharmaceutical companies...
Ebola survivors have a ‘unique’ retinal scar
Researchers have conducted a study of Ebola survivors to determine if the virus has any specific effects on the back on the eye using an ultra widefield retinal camera.
Using single-cell RNA sequencing to track stem cell development
Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal.
New lung ‘organoids’ in a dish mimic features of full-size lung
'Mini organs' may aid in understanding and treating respiratory diseases.