Role of enzyme in tumour immune microenvironment identified
Researchers have found that reducing glycosylation on the T cell surface may offer new approaches to cancer immunotherapy.
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New molecule disrupts pathways that promote cancer growth
Researchers have discovered a molecule that binds to a cancer cell protein, stopping growth of breast and ovarian tumours.
New small molecule blocks immune response signalling pathway
A new small molecule has great promise for the treatment of autoimmune diseases by inhibiting the proinflammatory signalling pathway.
Pulmonary ionocytes: unexpected discovery has implications for CF
Researchers found surprising function of pulmonary ionocytes which may affect how cystic fibrosis drugs work.
Key epitope can trigger tumour cell death
An epitope on CD95 receptor causes tumour cells to self-destruct and may prolong benefits of CAR T-cell therapy for solid tumours.
Microcapsule-loading exosomes to treat vitreoretinal diseases
Scientists have developed ExoCaps, self-healing microcapsules that are more feasible than other cell-based technologies.
Intratumoural bacteria drives radiation therapy resistance
Lactate producing bacteria is responsible for rewiring metabolic signalling pathways, causing resistance to radiation therapy.
mRNA reverses the glioblastoma immunosuppressive environment
Extracellular vesicles loaded with mRNA encoding interferon-gamma offers promise for treating difficult tumours.
New 3D tumour models simulate complex tumours
3D tumour models enable scientists to offer better treatments and improve survival outcomes for complex conditions like breast cancer.
Cancer-killing T cells enhanced by engineered bacteria
Bacteria programmed to paint targets on solid tumours for T cells to see eliminates the need for specific antigens.
Huntington’s disease: a way to prevent cognitive decline
Discovery about Huntington’s disease may apply to other neurodegenerative disorders, like Alzheimer’s and frontotemporal dementia.
New material engineered can repair severed nerves
Researchers designed the first magnetoelectric material that precisely stimulates neurons to treat nerve damage.
Protective mutation found in kidney disease gene
A new discovery about a different protective genetic mutation in apolipoprotein L1 could have major implications for kidney health.
SCID-X1 gene therapy successful with 3D genome architecture
New research improves patient care by finding where gene copies integrate into DNA and using lentiviral vectors.
Human-derived proteins used in DREAM tool
CRISPR-DREAM tool used to activate insufficiently expressed genes and convert skin cells to induced pluripotent stem cells (iPSCs).
