Enzyme substrate mutations promote tumour growth
Using a newly developed algorithm and a validation study, US researchers find that cancer hijacks a class of enzyme mutations to fuel tumorigenesis.
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Genome-edited iPSCs show promise for treating Fabry Disease
Japanese researchers successfully engineered iPSCs to secrete a modified enzyme, mNAGA, and restored enzyme activity in vitro and in a mouse model, opening new avenues for regenerative medicine for conditions such as Fabry Disease.
Novel hydrogel brings hope for infertility and fertility challenges
South Korean researchers have developed a hydrogel using a uterus-derived decellularised extracellular matrix, bringing hope for those challenged with infertility.
How do cells control the secretion of mucin and insulin?
Spanish researchers looking at two crucial proteins uncover how cells release mucin and insulin, leading to new methods to reset deregulation.
Higher levels of lean muscle may protect against Alzheimer’s disease
Individuals with higher levels of lean muscle may have a reduced risk of developing Alzheimer's disease. While further research is needed to understand the underlying biological pathways and implications for clinical practice, these findings shed light on the potential role of lean muscle in protecting brain health.
Non-invasive photonic radar system enables precise health monitoring
Cane toad breathing monitored using ‘photonic radar’ at millimetre scale acts as proof of principle for human health detection in clinical environments
Lupus flare-ups linked to bacterial growth in gut
US researchers find that recurrent bouts of systemic lupus erythematosus is closely tracked with measurable upticks in growth in the gut of a certain species of bacteria.
New immunotherapy combination improves efficacy in animal models of liver cancer
Researchers at the Cima University of Navarra lay the foundations for the application of an immunotherapy combination in patients with the liver cancer: hepatocellular carcinoma.
New insights into influenza A’s infiltration of host cells
US researchers have made a significant breakthrough in understanding how the influenza A virus takes over host cells while minimising damage to itself. By studying the protein PA-X, they found that the virus uses a surgical strike approach, selectively degrading host cell RNA while preserving its own replication, shedding light…
Human Brain Project study offers insights into neurotransmitter receptor organisation
Researchers from the Human Brain Project (HBP) and collaborating institutions have made significant strides in understanding the distribution of receptors in the brain. Through a comprehensive mapping study, they discovered two distinct gradients of receptor expression per neuron in the cortex, shedding light on its organisation and functionality.
Combination therapy effective against canine melanoma
A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.
Drug helps reduce bacterial antibiotic resistance
US researchers uncover a new drug that reduces the ability of bacteria to develop antibiotic resistance, prolonging the antibiotic effectiveness.
Revolutionary way to measure proteins aids precision medicine advancements
Using a nanofluidic aptamer nanoarray to measure biomolecules including proteins, Japanese researchers are attempting to bridge the gap for precision medicine
New detection system for viral infections helps vaccine and drug development
Out of the US, a newly developed a rapid, stain-free, and automated viral plaque detection system enabled by holography and deep learning, is a cost-effective way of observing the formation of viral plaques caused by viral infections over a layer of cells.
Extraocular muscles may hold key to defensive mechanisms against ALS
According to Swedish study, muscle fibres found in extraocular muscles seem to be resistant and even increase in proportion in those with ALS. This offers new treatment avenues for slowing down the disease.