‘Chemical cube’ tools for building new drugs
In an ongoing discovery programme, a chemical-creation platform is being revealed – based on cubic molecules – that could help breathe new life into tired drugs.
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In an ongoing discovery programme, a chemical-creation platform is being revealed – based on cubic molecules – that could help breathe new life into tired drugs.
The researchers found that cancer cells with thicker glycocalyx barrier are better at evading immune cells.
The natural process of removing damaged cell parts could present an alternative to antibiotics, especially where bacteria have become resistant to existing drugs.
Scientists from Spain have identified genes that regulate Alzheimer’s disease, including Surf4, which alters the regulation of calcium within Alzheimer’s cells.
The Omicron variant of the SARS CoV-2 virus has previously had a number of break-through infections. However, researchers have discovered that antibodies present in previously infected patients can neutralise variants of the COVID-19 disease.
The scientists from Texas A&M have developed GTX-102, a novel therapeutic candidate to target Angelman syndrome by reactivating expression of deficient protein.
US researchers discover compound that limits weight gain in mice with a high-sugar diet, by lowering the mitochondrial magnesium.
US discovery opens the way to drugs that can prevent T cell therapies from losing their potency over time.
Japanese researchers discover the mechanism of inhibition of diet-induced obesity in mice by the glucose-dependent insulinotropic polypeptide
The finding is an critical first step towards classifying lesions on the pancreas that are at highest risk of becoming cancerous, enabling their removal before they start to spread.
Results from a US study in cells and mice may have implications for the development of a new class of anticancer drugs against liver cancer.
Using gene therapy, the researchers corrected abnormal heart rhythms by restoring a protein that heart cells need to establish connections with one another.
US scientists suggest that anti-angiogenesis drugs could improve the function and delivery of CAR-T cell therapy.
New urine gene test presented at EAU identified mutations across 10 genes, that were able to predict bladder cancer.
The researchers say their new discovery could be used to design better vaccines and to gain a deeper insight into autoimmune diseases and allergies.