Scientists discover therapeutic target that could treat glaucoma
The researchers found restoring mitochondrial homeostasis in the diseased neurons could protect the optic nerve cells from being damaged from glaucoma.
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Researchers find ancient virus genome drives autism
The scientists revealed in mice models that endogenous retrovirus activation increases a foetus’s susceptibility to autism.
Enzyme opens door to new therapeutic targets for cellular stress
The activity of enzyme ATE1, as seen by US researchers, flags misfolded proteins for destruction and is enhanced by binding iron-sulphur clusters.
Transporting antibodies across the blood–brain barrier to treat Alzheimer’s disease
Researchers have found a way to ensure that new Alzheimer’s medications are delivered to the right place in the body and at the right timepoint in disease progression, so that they have the best effect.
Novel peptide may tackle the root cause of type 2 diabetes
British researchers uncover peptide: PEPITEM that could reduce the risk of type 2 diabetes and other obesity-related conditions.
Researchers discover the role of intestinal fibrosis in inflammatory bowel disease
The scientists used a new in vitro platform, which allowed intestinal organoids to be cultured on an open lumen, planar system that could be manipulated experimentally.
New self-powered drug delivery system
US researchers have invented a drug delivery technology that has implications for opioid epidemic, cancer treatment, rehabilitation care and more.
Research shows lipid nanoparticles are highly effective in gene therapy
Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.
Could long Covid be solved by autoantibodies?
Swiss researchers have found a new class of 'good autoantibodies', which are associated with a favourable course and lower risk of long-Covid.
Stopping immune cell leakage from tumours could improve skin cancer treatment
Results show the number of specialised immune cells available for fighting skin cancer doubled when a new treatment blocked their escape from melanoma tumours.
New hydrogel stem cell treatment could repair injured brain tissue
The new ‘hybrid’ hydrogel allowed researchers to safely deliver stem cells to the site of a brain injury in mice.
Transplanted brain organoids show response to visual stimuli in adult rats
Researchers say that by looking at individual neurons, they were able to gain a deeper understanding of the integration of transplanted brain organoids.
Scientists create organoid to understand hearing loss
The ground-breaking study is an important step towards modelling cochlear function in a dish.
Researchers develop organoid models to study non-alcoholic fatty liver disease
The team used these models to show drug responses and established a CRISPR-screening platform to identify potential therapeutic targets for non-alcoholic fatty liver disease.
Weaponising SARS-CoV-2 spike protein against itself to prevent infection
By creating a drug that is based on part of the SARS-CoV-2 spike protein, US and Finnish researchers can block the virus from entering cells.