Stem cell model shows early stages of differences in sex development in mice and humans
Israeli researchers develop new model that will help pinpoint complications in individuals with Differences in sex development (DSD).
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Synthetic tissue helps restore and repair erectile function in animal models
Chinese scientists have developed a synthetic tissue that repairs penile injuries and restores normal erectile function in pigs.
A promising oral drug delivery platform could replace injections with pills
The researchers explored the possibility of using the probiotic bacteria Lactobacillus reuteri as a novel oral drug delivery platform to treat rheumatoid arthritis in an animal model.
50 year old blood pressure drug offers alternative treatment for PTSD
US scientists offer a new purpose for the blood pressure drug clonidine as a treatment to reduce the affects of PTSD.
Protein Grb10 offers a potential new approach for treating obesity
The researchers found that the protein Grb10 promotes leptin activity in the brain, opening the possibility of developing Grb10-based new approaches to treat obesity.
Novel cancer vaccine simultaneously kills and prevents brain cancer
US researchers develop a dual-action cell therapy engineered to eliminate established tumours and train the immune system to eradicate primary tumour and prevent cancer’s recurrence.
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
The researchers argue hepatocytes are susceptible to SARS-CoV-2 pseudovirus infection and propose that metformin could be a therapeutic option to attenuate SARS-CoV-2 infection in patients with fatty liver.
Scientists identify a biomarker that predicts CAR T-cell therapy efficacy
Combining AI with cutting-edge flow cytometry and massive sequencing technologies, researchers describe CAR T cell characteristics that determine their therapeutic capacity for the first time.
New method precisely locates gene activity and proteins across tissues
The scientists argue the technique enables the creation of complex, data-rich “maps” of organs, including diseased organs and tumours, which could be widely useful in pre-clinical research.
Life-saving approach may overcome persistent obstacles to cell transplantation and immunotherapy
In their study, researchers duped antibodies with a decoy to prevent rejection of transplanted cells.
Researchers generate organoid model for gastroesophageal junction cancer
The scientists discovered that dual knockout of genes in organoids grown from human tissue can generate a model of a potential therapeutic target for gastroesophageal junction cancer.
Researchers have sculpted the human body plan in a dish
The scientists hope the human body plan will increase the understanding of the aetiology and pathology of disease.
Spatial lung cell atlas offers insights into disease and immune function
Researchers have genetically profiled nearly 200,000 cells from lungs, mapping their precise locations in tissue to discover an unexpected new immune niche in our airways.
New therapeutic strategy could reduce cardiovascular disease in cancer survivors
US researchers have discovered that cancer treatments or anthracycline drugs, cause cardiovascular disease by activating a key inflammatory signalling pathway.
Harnessing AI technology for IVF embryo selection
A US study used an AI algorithm to determine chromosomal numbers in IVF embryos.