Cancer therapy shows potential to treat severe COVID-19 patients
Pre-clinical experiments involving cells from ICUs patients infected by SARS-CoV-2, and mice infected by MHV-A59 (murine hepatitis virus A59) show promise in treating COVID-19.
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Simcere receives clearance to investigate a bi-functional fusion protein drug
The FDA has cleared the Simcere's investigational new drug application for SIM0237, an anti-PD-L1/IL-15 bi-functional fusion protein, for the treatment of adult patients with advanced solid tumours.
Newly discovered GPCR signalling process opens possibility for novel therapies
US researchers have found that G protein-coupled receptors function in a way not previously known, which suggests untapped potential.
Targeting of immune cells slows cancer growth in pre-clinical studies
Researchers have discovered a new cancer immunotherapy approach that shrinks solid tumours.
New study expands range of potential Alzheimer’s drugs
Researchers have connected the loss of alpha-B insulin receptors in brain microvessels as contributors to insulin resistance and cognitive decline, with Alzheimer’s disease.
“Slow” vaccine delivery improves immune response to HIV
An experimental HIV vaccine, delivered as increasing doses over several days, led to long-lasting and diverse antibody production in monkeys.
New findings show a monoclonal antibody could target heroin addiction
The study highlights that a monoclonal antibody that targets heroin is effective in blocking the psychoactive and lethal effects of drug abuse in mice.
Enhanced reprogrammed heart fibroblasts delivered into heart muscle cells
UAB researchers have found that adding TBX20 to the reprogramming cocktail MGT 133 promoted cardiac reprograming.
Automated liquid handlers market set to record $242.84m growth
A report has found that increased investment in drug discovery will help the demand for personalised medicine, encouraging the growth of the liquid handling market.
New method to label proteins could help track disease
Scientists have developed a new method to study the proteins released by cells, which could lead to the development of new tools to track diseases including cancer.
Researchers develop an accurate single-cell electrorotation microfluidic device
The technology works by using an electric field to first capture a single cell in a microfluidic device, followed by applying a rotating electric field to rotate the trapped cell and then measuring the rotation speed.
In vitro hair follicle model grown in culture
Scientists have developed a new strategy to generate hair follicles in vitro with potential useful applications for treating hair loss, animal testing and drug screening.
3D map reveals DNA organisation within human retina cells
Scientists shed light on how genetic architecture in human retina cells determine gene expression, tissue-specific function, and disease phenotype in blinding diseases.
Pre-clinical trials show drug inhibits inflammasome in COVID-19 cases
Anti-inflammatory effects of niclosamide, observed in a new pre-clinical study, were due to inhibition of the inflammasome, a protein complex presented in the interior of defence cells.
Novel AI model could accelerate drug discovery and precision medicine
A new AI model can accelerate drug discovery by accurately predicting human response to novel drug compounds.