Making lab-grown brain organoids ‘brainier’
UCLA-led team discovers that using early-stage stem cells is a key to producing structures that are reliable models of disease.
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Researchers develop a new method for testing protein-based drugs
Researchers say a newly developed lab technique could spark a “paradigm shift” in biopharmaceuticals testing, promising to speed up drug discovery and development of protein-based drugs.
Researchers have developed a drug that can break through the mucus barrier
A capsule that tunnels through mucus in the gastrointestinal tract could be used to orally administer large protein drugs such as insulin.
Newly discovered protein could be used to produce life-saving antifungals
Researchers have discovered a protein, Ait1, that is responsible for controlling cell growth in yeasts. Since humans and yeasts have remarkably similar cellular mechanisms, teasing out the differences presents drug developers with new target.
Researchers discover a new way charged macromolecules self-assemble
Researchers found that uniformly charged macromolecules — or molecules, such as proteins or DNA, which contain many atoms all with the same electrical charge — can self-assemble into very large structures.
Scientists inhibit cancer cell growth using pyrrolizidine alkaloid
Researchers in Japan have succeeded in inhibiting cancer cell growth using pyrrolizidine alkaloid, a component of plant origin previously thought to be too toxic to administer.
Novel 3D microfluidic device to uncover complicated processes within the placenta
The ‘placenta-on-a-chip’ microfluidic device mimics a malaria-infected nutrient exchange between mother-foetus.
Artificial intelligence model finds potential drug molecules a thousand times faster
A geometric deep-learning model is faster and more accurate than state-of-the-art computational models, reducing the chances and costs of drug trial failures.
6 reasons to attend Drug Discovery 2022… especially if you are an early career professional
Europe’s largest meeting for life sciences professionals is just around the corner – be a part of it. This year, Drug Discovery 2022 is coming to the ever-buzzing ExCel centre in London from 4-5 October and will focus on ‘driving the next life sciences revolution’ as we build new momentum…
New scientist at Rockefeller University plans to unlock vast chemical spaces for drug discovery using algorithms
Jiankun Lyu hopes to use algorithms to find improved drugs by screening chemicals that may look different to a protein’s known ligands but work in a similar way.
AI-based screening method could boost speed of new drug discovery
Using an AI algorithm that models drug and target protein interactions, researchers achieved up to 97 percent accuracy in identifying promising drug candidates.
New study demonstrates an in silico reaction screening strategy for reaction development
Through the novel screening strategy, the researchers were able to develop a suit of 48 reactions that produce compounds that are potentially useful for new drugs.
Newly discovered SARS-CoV-2-like virus could infect humans and resist vaccines
A recently discovered SARS-CoV-2 virus in a Russian bat is likely to be capable of infecting humans and resistant to current vaccines.
Novel screening reveals drug candidates for Huntington’s disease
Researchers have developed a new method that enables high-throughput screening of Huntington’s disease organoids.
High-throughput screening reveals compounds that inhibit SARS-CoV-2 replication
Researchers have used a high-throughput assay to screen for potential small molecule SARS-CoV-2 replication inhibitors.