Improved AAV could cross blood-brain barrier and deliver gene therapies to CNS
A newly developed AAV has shown promise at delivering gene therapies to the brain in mice and non-human primates.
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Powerful computer modelling approach developed to simulate cells
A study has proposed a new technique for modelling living cells at atomic resolution, which could be used to research human health.
New gene target for small-cell lung cancer discovered
Deleting the gene POU2AF2 kills cancer cells in deadly subtype of small-cell lung cancer.
New drug has potential to turn COVID-19 virus against itself
The Scripps Research team showed that a variation of an already FDA-approved therapeutic for neurological disease can block COVID-19 infection in animals.
Scientists discover multiple pathways of the 5HT2a receptor activated by psychedelics
The new LSD-like compounds activated the 5HT2a receptor, a receptor stimulated by serotonin, without causing hallucinations.
New study highlights how to deliver a protein to the brain quickly
Potential uses for the study could include repairing spinal cord injuries and a range of other localised injection applications.
Making lab-grown brain organoids ‘brainier’
UCLA-led team discovers that using early-stage stem cells is a key to producing structures that are reliable models of disease.
Researchers develop a new method for testing protein-based drugs
Researchers say a newly developed lab technique could spark a “paradigm shift” in biopharmaceuticals testing, promising to speed up drug discovery and development of protein-based drugs.
Researchers have developed a drug that can break through the mucus barrier
A capsule that tunnels through mucus in the gastrointestinal tract could be used to orally administer large protein drugs such as insulin.
Newly discovered protein could be used to produce life-saving antifungals
Researchers have discovered a protein, Ait1, that is responsible for controlling cell growth in yeasts. Since humans and yeasts have remarkably similar cellular mechanisms, teasing out the differences presents drug developers with new target.
Researchers discover a new way charged macromolecules self-assemble
Researchers found that uniformly charged macromolecules — or molecules, such as proteins or DNA, which contain many atoms all with the same electrical charge — can self-assemble into very large structures.
Scientists inhibit cancer cell growth using pyrrolizidine alkaloid
Researchers in Japan have succeeded in inhibiting cancer cell growth using pyrrolizidine alkaloid, a component of plant origin previously thought to be too toxic to administer.
Novel 3D microfluidic device to uncover complicated processes within the placenta
The ‘placenta-on-a-chip’ microfluidic device mimics a malaria-infected nutrient exchange between mother-foetus.
Artificial intelligence model finds potential drug molecules a thousand times faster
A geometric deep-learning model is faster and more accurate than state-of-the-art computational models, reducing the chances and costs of drug trial failures.
6 reasons to attend Drug Discovery 2022… especially if you are an early career professional
Europe’s largest meeting for life sciences professionals is just around the corner – be a part of it. This year, Drug Discovery 2022 is coming to the ever-buzzing ExCel centre in London from 4-5 October and will focus on ‘driving the next life sciences revolution’ as we build new momentum…