Optimising human small intestinal organoids by implementing Paneth cells
Researchers have succeeded in developing organoids that contain mature Paneth cells, which were not present in the previous human small intestinal organoids.
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Scientists develop promising new gonorrhoea antibiotic
The drug candidate, JSF-2659, has been developed to be administered orally, and could be a game changer in treating gonorrhoea.
Stem cells could repair spinal cord injuries
Researchers have identified latent stem cells that could respond to spinal cord injuries.
Study reveals novel insights into Crohn’s disease
The findings by Massachusetts General Hospital could point to a potential target to treat Crohn’s disease.
A modified TB vaccine could treat bladder cancer
An animal study has shown that a modified vaccine for tuberculosis could treat bladder cancer whilst minimising side effects.
Genomic studies could impact pneumococcal disease vaccine design
A recent genomic surveillance study has demonstrated the value of genomics to inform vaccine design and highlight the challenge posted by shapeshifting bacteria.
Researchers develop a small molecule that makes immunotherapy available to all cancer patients
Scientists have identified and synthesised a small molecule that could be a more accessible and affective alternative to an antibody that treats a wide range of cancers.
New vaccine protects mice against RSV
The new RSV vaccine formulation protected newborn mice against infection and evoked strong responses in immune cells from human newborns.
First captured image of antigen-bound T-cell receptor at near-atomic resolution
Using cryo-electron microscopy, researchers have captured the structure of a membrane-bound T-cell receptor complex with bound antigen.
Unravelling cell biology through artificial intelligence
The AI algorithm was able to predict the presence and the location of nuclei in more than 8,000 cells.
New research finds cancer-associated fibroblasts can promote or inhibit drug sensitivity
Researchers found that fibroblasts had varying effects on tumour cells based on both the type of non-small cell lung cancer and the drug used for treatment.
Peptide delivered by nasal spray can reduce seizure activity
A novel peptide augments the brain’s natural mechanism to help prevent seizures and protect neurons in research models of both Alzheimer’s and epilepsy.
Targeted cancer vaccines eliminate tumours and prevent recurrence in mice
Researchers have developed an mRNA-based cancer vaccine that is delivered directly into the lymphatic system for a more potent response.
New method enables efficient sample preparation for single-cell proteomics
Scientists develop a novel single-cell proteomics technique based on water droplet-in-oil digestion to enable efficient protein recovery.
New machine learning technique to accelerate the process of drug screening
Researchers have developed a machine learning method to quantitatively analyse and compare microscopy images of proteins.