Human urine-derived stem cells have robust regenerative potential
A new study provides the possibility to evaluate the capacity of telomerase-positive human urine-derived stem cells to become a wide variety of other cell types.
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New brain mechanism involved in cocaine addiction has been identified
Researchers have found that blocking certain acetylcholine receptors in the lateral habenula made it harder to resist seeking cocaine in a rat model of addiction.
Researchers have linked resistance to kidney cancer treatment to low mitochondrial content in cancer cells
When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment.
Dysfunctional gene leads to potentially treatable deafness
Researchers have found that inherited mutations in the MINAR2 gene causes deafness. The findings suggest that deafness could be treated with genetic therapies.
Using microscopy to understand how bacteria spreads and multiplies
Researchers have been using state-of-the-art microscopy to analyse bacteria’s shapeshifting behaviour, findings which could lead to treatments for UTIs.
Scientists identify the molecular mechanisms behind learning and memory
Researchers identify how acetylcholine sets off a signal cascade in brain cells that directly influence aversive learning and memory formation. The findings may open door to new therapeutic strategies for Alzheimer’s disease.
Promising anticancer molecule identified
Researchers have identified a DNA-derived molecule that binds to and inhibits the function of CYP24 and shows promising antiproliferative activity.
NRG Therapeutics to develop small molecule disease-modifying medicines for debilitating chronic neurodegenerative disorders
NRG is developing a pipeline of brain-penetrant small molecule inhibitors of the mitochondrial permeability transition pore (mPTP) with potential as first-in-class treatments for Parkinson's disease and motor neuron disease.
An effective and error-free gene editor
Scientists have developed a new gene editor which uses a modified pair of molecular scissors that make nicks on opposite strands of the DNA at two different points.
New £4.25 million grant kick starts UK-wide collaborative research effort to end motor neuron disease
A £4.25 million research grant has been awarded seeks to discover meaningful MND treatments within years.
Listeria-based booster improves vaccine’s protection against recurring cancer
New research has shown that using viral and bacterial vaccine approaches together is safe and far more effective at fighting the cancer than either approach by itself.
Repurposed drug inhibits enzyme related to COVID-19
Researchers have found that an already existing drug compound could block the activity of a key enzyme of COVID-19.
Scientists discover new molecule that kills hard-to-treat cancers
Scientists have synthesised a new molecule that could kill a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, by exploiting a weakness in cells not previously targeted by other drugs.
How tumours change immune cells to promote cancer growth
Researchers have found that soft-tissue sarcomas change the biology of immune cells surrounding tumours to promote tumour growth
Novel combination therapy could eliminate colon tumours
Researchers have found that a combination therapy that incorporates a plant virus with an immune cell-activating antibody clears colon cancer in mice.