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Researchers find that CRISPR gene editing can give rise to cell toxicity and genomic instability

11 August 2022 | By Ria Kakkad (Drug Target Review)

Using computational methods, researchers analysed the most popular CRISPR library designed for human cells and found 3,300 targeted spots that show strong toxic effects.

Abstract Structure Background Gold Molecule Or Atom,3d rendering

Novel streamlined screening method could discover new horizons in chemical reaction design

10 August 2022 | By Ria Kakkad (Drug Target Review)

An in-silico reaction screening strategy could produce compounds potentially useful for novel drug development.

medicine and medical laboratory cell culturing at the safety cabinet

Scientists have identified novel molecular biomarkers in cells that spread triple-negative breast cancer

9 August 2022 | By Ria Kakkad (Drug Target Review)

The researchers identified key molecular differences between triple-negative breast cancer cells that cling to an initial tumour and those that venture off to form distant tumours.

Someone hollding brain scans showing alzheimer's disease on MRI

Novel insights into the genetic and molecular machinery that causes Alzheimer’s disease

9 August 2022 | By Tony Portelli (Drug Target Review)

Researchers have gained a clearer understanding of the genetic and molecular machinery in human microglia, findings that may provide insight into Alzheimer’s diseases development.

Coronavirus vaccine vector background. Covid-19 corona virus vaccination with vaccine bottle and syringe injection tool for covid19 immunization treatment. Vector illustration.

Nanoparticle vaccine protects against a range of COVID-19 variants

8 August 2022 | By Ria Kakkad (Drug Target Review)

The vaccine attaches spike proteins from SARS-CoV-2 and seven other SARS-like betacoronaviruses to a protein nanoparticle structure, to induce the production of a broad spectrum of cross-reactive antibodies.

Doctor and holographic bowel scan projection with vital signs and medical records.

Newly identified compound reduces potency of Shiga toxin

5 August 2022 | By Ria Kakkad (Drug Target Review)

Scientists have identified a molecule that can bind to a lethal subtype of the bacterial Shiga toxin, suppressing its deadly effects.

A new study has highlighted how an antibody strengthens bonds between cells

5 August 2022 | By Ria Kakkad (Drug Target Review)

The monoclonal antibody 19A11 binds E-cadherin, a protein that helps cells stick together, especially in epithelial layers that line the skin, the gut and other organs.

Colon cancer. Cancer attacking cells. 3d illustration

Scientists uncover new therapeutic target for treating colorectal tumours

4 August 2022 | By Ria Kakkad (Drug Target Review)

New study has demonstrated that mice deficient in dendritic cell immunoreceptor are resilient against colitis and colonic tumour growth.

Llama nanobodies could prevent a deadly post-transplantation infection

4 August 2022 | By Ria Kakkad (Drug Target Review)

A new study has shown that nanobodies derived from llamas could have the potential to destroy human cytomegalovirus.

Gene therapy approach shows promise in treating ALS

3 August 2022 | By Ria Kakkad (Drug Target Review)

In rodent models of ALS, the introduced neuroprotective protein slowed disease progression and increased life span.

Mitochondria, Cross section view of a mitochondrion 3d illustration

Using optogenetics to restore cell function

3 August 2022 | By Ria Kakkad (Drug Target Review)

In a new study, researchers have found that light can be used to naturally balance a cell’s mitochondria.

Magnetic resonance imaging Finding 5 cm isodense mass with ill-defined margin and surrounding edema at Left frontal lobe. Glioblastoma, brain metastasis.science and education mri brain background.

An EGFRvIII-targeted immune-based therapy could potentially treat glioblastoma

3 August 2022 | By Ria Kakkad (Drug Target Review)

A T-cell bispecific antibody shows potent anti-tumour activity in preclinical models of epidermal growth factor receptor variant III (EGFRvIII) mutant glioblastoma.

parents' day concept with father-mother or nurse and children supporting red heart together

New study provides insight for how congenital heart defects manifest

2 August 2022 | By Ria Kakkad (Drug Target Review)

The researchers have found that the cells lining the heart direct the cardiac muscle to grow until the heart reaches its full size.

Elderly man is holding his hand while eating because Parkinson's disease.

Scientists create a nanobody that could treat Parkinson’s disease

1 August 2022 | By Ria Kakkad (Drug Target Review)

Researchers have developed a nanobody that can penetrate the tough exterior of brain cells and untangle misshapen proteins that lead to Parkinson’s disease.

The silhouette of a blind man with a cane and glasses. People stand in a line and support the yellow figure by the hands.

Progress towards a stem cell-based therapy for blindness

1 August 2022 | By Ria Kakkad (Drug Target Review)

Scientists are developing an effective stem cell-based therapy to regenerate photoreceptors cells and restore sight in people with blindness.

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