Cilia-free stem cells could open a new way to study rare diseases
A new study has shown that cilia-free human pluripotent stem cells could help scientists understand the causes of polycystic kidney disease and other cilia-linked illnesses.
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A new polymer system promises to revolutionise drug delivery
Scientists have engineered a new class of material which is able to both withstand the harsh acidic conditions of the stomach and then dissolve predictably in the comparatively gentle environment of the small intestine.
Nose organoids reveals first stages of SARS-CoV-2 and respiratory syncytial virus infection
Using nose organoids, researchers have highlighted key differences between the infection by SARS-CoV-2 and that of respiratory syncytial virus.
Brain organoids may boost drug screening for neurological disorders
Neuroscientists have designed brain organoids to contain both mature neurons and astrocytic glial cells in relative proportions like the human brain.
New study highlights the mechanism of G protein-coupled receptors
Scientists have gained new insights into the way G protein-coupled receptors operate, a step toward the development of improved drugs with fewer side effects.
An epigenetic cause of miscarriages has been identified and cured in mice
Researchers have discovered that failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities.
University at Buffalo to develop drugs that stop ovarian cancer from feeding on fat
The University at Buffalo has received a $2.3 million grant from the US National Cancer Institute to identify metabolic vulnerabilities of ovarian cancer and to develop potential treatments for the disease.
The power of T-cell immune response to Omicron variants
In a new study, researchers have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2.
Chemical markers that may unlock future therapeutic uses of messenger RNA
Researchers have found new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes.
Study reveals cellular diversity of oesophageal tissue
Researchers defined 11 subsets of cells found in the oesophagus of mice. These findings could potentially help clinicians diagnose or treat certain types of cancer.
Reducing sclerosis inflammation in mice
Researchers have been able to reduce the chronic inflammation associated with multiple sclerosis in a mice model of the disease, by administering one of the resolving lipid mediators of inflammation, Maresin-1.
New study shows reprogrammed macrophages promote spread of breast cancer
The new findings could help scientists to identify new targets and develop initial concepts to better restrain the metastatic spread of breast cancer.
A three-dimensional model for rare neuromuscular disorders
Scientists have created a tiny, bioengineered 3D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.
Personalised organoid models for rare spinal cancer
Scientists have successfully created viable organoids from tumour samples from five patients with a rare bone cancer called a chordoma, which has few therapeutic options.
Whole genome sequencing study reveals hidden insights about the causes of cancer
DNA analysis of thousands of tumours has uncovered insights about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.