Brain organoids may boost drug screening for neurological disorders
Neuroscientists have designed brain organoids to contain both mature neurons and astrocytic glial cells in relative proportions like the human brain.
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New study highlights the mechanism of G protein-coupled receptors
Scientists have gained new insights into the way G protein-coupled receptors operate, a step toward the development of improved drugs with fewer side effects.
An epigenetic cause of miscarriages has been identified and cured in mice
Researchers have discovered that failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities.
University at Buffalo to develop drugs that stop ovarian cancer from feeding on fat
The University at Buffalo has received a $2.3 million grant from the US National Cancer Institute to identify metabolic vulnerabilities of ovarian cancer and to develop potential treatments for the disease.
The power of T-cell immune response to Omicron variants
In a new study, researchers have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2.
Chemical markers that may unlock future therapeutic uses of messenger RNA
Researchers have found new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes.
Study reveals cellular diversity of oesophageal tissue
Researchers defined 11 subsets of cells found in the oesophagus of mice. These findings could potentially help clinicians diagnose or treat certain types of cancer.
Reducing sclerosis inflammation in mice
Researchers have been able to reduce the chronic inflammation associated with multiple sclerosis in a mice model of the disease, by administering one of the resolving lipid mediators of inflammation, Maresin-1.
New study shows reprogrammed macrophages promote spread of breast cancer
The new findings could help scientists to identify new targets and develop initial concepts to better restrain the metastatic spread of breast cancer.
A three-dimensional model for rare neuromuscular disorders
Scientists have created a tiny, bioengineered 3D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.
Personalised organoid models for rare spinal cancer
Scientists have successfully created viable organoids from tumour samples from five patients with a rare bone cancer called a chordoma, which has few therapeutic options.
Whole genome sequencing study reveals hidden insights about the causes of cancer
DNA analysis of thousands of tumours has uncovered insights about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.
New screening technique to accelerate the discovery of cancer-fighting drugs
The novel screening technique can identify molecules that can disable dangerous proteins before they cause diseases by blocking them from interacting with a cell’s DNA.
A machine learning model that could identify antibody targets
Using a machine learning model, scientists could predict not only the virus an antibody will attack, but which features on the pathogen the antibody binds to.
Extracellular vesicles: a new target for understanding endocrine disorders
Scientists at the Endocrine Society have found extracellular vesicles may offer new insights into treating endocrine disorders.