Experimental mRNA HIV vaccine shows promise in pre-clinical studies
A new potential mRNA vaccine that delivers instructions for making two key HIV proteins has been tested in mice and rhesus macaques.
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Ingenious AI method for improved target identification
A research team based at Skoltech in Russia has developed an artificial intelligence-driven solution for highly accurate detection of efficacious binding sites to expedite drug discovery.
Altasciences acquires Sinclair Research and continues to expand pre-clinical platform
Altasciences has announced its acquisition of Sinclair Research, a pre-clinical CRO, to expand its services across the US.
Novel method for chemo capture – up to three times more effective
A team of researchers in the US has devised a new means of removing excess chemotherapy drugs from a patient’s bloodstream, with potential for wider clinical and materials science applications.
Collaborative research efforts enabled rapid response to Omicron variant
News from the Pasteur Institute in France reports on how multi organisational efforts of numerous research institutes enabled the scientific community to gain key insight into the Omicron variant, facilitating a rapid life-saving response.
Virtual method enables screening of billions of chemical compounds
A new platform, named Virtual Synthon Hierarchical Enumeration Screening, has been developed by researchers to efficiently discover drugs.
Scientists discover compound to combat multidrug-resistant bacteria
Taking a novel approach to antibiotic discovery, researchers at Rockefeller University have hit upon a promising solution to the problem of superbugs – a pervasive threat in hospitals the world over.
Scientists develop means to boost the power of CRISPR
The capability to edit genes has been transformative in opening therapeutic avenues for hitherto untreatable diseases and aiding biological insight. Scientists have now discovered a way to enhance this process using retrons, making the process more efficient and effective.
Nanoparticle delivery of CRISPR enables genome editing of vascular endothelium
According to researchers, a new method to deliver CRISPR-Cas9 to vascular endothelial cells could be used to treat many diseases, including COVID-19.
Model insight into blood enzyme Lp-PLA2 could aid cardiovascular health
A new study in the US has used a computer model to reveal the mechanism of action of lipoprotein-associated phospholipase A2 – a biomarker for cardiovascular disease.
Promising new gene therapy approach for LGMD2B
Researchers at Children’s National Hospital in the US have developed a promising new gene therapy for limb-girdle muscular dystrophy (LGMD) 2B.
Antibodies that can neutralise SARS-CoV-2 Omicron variant identified
A study has revealed four classes of antibodies that can neutralise Omicron by targeting one of four areas of the spike protein present in SARS-CoV-2 variants.
Antibody drug target identified for influenza viruses
Researchers have found a small subset of antibodies that target a site at the base of the influenza virus hemagglutinin protein.
New antibody delivery system could improve precision medicine
Scientists have developed a metal-organic framework that, when attached to antibodies, improved their targeted delivery in in vitro studies.
Cancer-promoting gene a potential target for pulmonary hypertension
The new study identified PDZ-binding kinase (PBK) as a promising target for pulmonary hypertension and assessed two PBK inhibitors.