Novel method refines cryogenic electron microscopy (cyro-EM)
The statistical method known as maximum entropy could improve cryogenic electron microscopy (cryo-EM) for more effective drug treatments.
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New antibiotic a possible alternative to treat Lyme disease
The antimicrobial hygromycin A was shown to clear Lyme disease in mice, representing a promising therapeutic against the disease.
Senescent cell treatment could combat age-related diseases
Scientists have developed a novel technique for the targeted clearance of senescent cells to improve treatments for ageing and other conditions.
Scientists identify protein that prevents HSV-1 brain damage
Mammalian target of rapamycin complex 2 (mTORC2) was found to prevent brain damage in mice infected with herpes simplex virus 1 (HSV-1).
Medicenna’s MDNA11 a promising alternative to checkpoint inhibitors
Medicenna's IL-2 super-agonist, MDNA11, successfully induced antitumour cells in animal models, a pre-clinical study has revealed.
Antibiotic-free hydrogel fights against drug-resistant bacteria
New dendritic hydrogels were tested against several infectious bacteria and could be used as an an antibiotic-free treatment in the future.
3D printed microneedle vaccine shows promise in animals
Researchers have shown that a new microneedle vaccine patch was 10 times stronger at generating an immune response in animals than a subcutaneous injection.
Highly potent antiviral against dengue could prevent spread of virus
A new antiviral has shown promise against the dengue virus in mice and has the potential to be used as a preventative measure.
New single-cell and metagenomic technique can characterise microbes
The metagenomic method, termed SMAGLinker, could improve the accuracy and resolution of microbial characterisation to improve medicine design.
Measuring microRNAs in blood may indicate dementia risk
Researchers identified three microRNAs whose levels were associated with mental performance in cells, mice and humans.
Mission Therapeutics receives $500k grant for Parkinson’s research
Mission Therapeutics was granted $500,000 from the The Michael J Fox Foundation for Parkinson’s Research for DUB inhibitor testing.
Neurolysin shown to be potential drug target for ischemic stroke
Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.
Scientists uncover answer to colorectal cancer immunotherapy resistance
Boosting dendritic cells prevented immunotherapy resistance in mouse models, suggesting a new approach to colorectal cancer therapies.
Wyss Centre initiates collaboration to improve brain tumour treatment
The Wyss Centre has announced a collaborative project to improve understanding of the brain cancer glioblastoma and develop new personalised therapies.
New vaccination approach could target “core” of all coronaviruses
Researchers have used genetically engineered SARS-CoV-2 Spike proteins to boost antibodies against a range of coronaviruses in mice.